「米国及び EUにおける内分泌かく乱物質の規制動向」

1 1 EU 2021 9 11 2 1. 2021 9 11 .. 3 1-1.. 3 EPA DIDP DINP 3 pfas .. 4 EPA 15 .. 4 pfas .. 6 EPA pfas .. 6 EPA pfas GenX .. 7 EPA PFOA PFOS .. 8 1-2.. 8 C9-C14 PFCA REACH XVII 8 ECHA SVHC .. 9 .. 9 ECHA .. 10 1-3.. 11 .. 11 1-4.. 11 EDC .. 11 2.. 14 2-1.. 14 2-2. EU .. 14 2-3.. 15 3 1. 2021 9 11 1-1. EPA DIDP DINP 2021 8 31 E PA DIDP DINP 2019 5 EPA 12 E PA 2020 11 2021 1 2020 12 EPA 9 ACC High Phthalates Panel Toy Association ACC ExxonMobil Chemical Company Teknor Apex EPA ACC 2021 3 ACC ExxonMobil Chemical Company Teknor Apex DIDP DINP EPA EPA Releases Final Scope Documents for Manufacturer-Requested Risk Evaluations of DIDP and DINP DIDP DINP EPA DIDP DIDP

2 Final Scope of the Risk Evaluation for Di-isodecyl Phthalate (DIDP) (1,2-Benzenedicarboxylic acid, 1,2-diisodecyl ester and 1,2-Benzenedicarboxylic acid, di-C9-11-branched alkyl esters, C10-rich) (CASRN 26761-40-0 and 68515-49-1) DINP DINP Final Scope of the Risk Evaluation for Di-isononyl Phthalate (DINP) (1,2-Benzene-dicarboxylic acid, 1,2-diisononyl ester, and 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich) (CASRNs 28553-12-0 and 68515-48-0) EPA ACC March 25, 2021 ACC 4 EPA ACC 2021 9 23 EPA Toy Association 2021 9 28 pfas 2021 9 7 2021 California Safer Food Packaging Cookware Act of 2021 AB 1200 9 13 10 6 2023 1 1 pfas 2024 1 1 2023 1 2024 URL QR 2021 10 5 pfas AB652 2023 7 1 12

3 pfas Health and Safety Code 104 Environmental Health 3 Product Safety AB1200 Plant-based food packaging: cookware: hazardous chemicals AB652 Product safety: juvenile products: chemicals: perfluoroalkyl and polyfluoroalkyl substances EPA 15 2021 9 8 E PA 15 Preliminary Effluent Guidelines Program Plan 15 Preliminary Plan 15 Effluent Guidelines 1 EPA 2 2 14 Effluent guidelines Program Plan 14 3 Preliminary Plan 2019 10 24 2021 1 11 EPA 15 1 2 3 5 EPA 15 pfas 3 Effluent Limitations Guidelines Organic Chemicals.

4 Plastics, and Synthetic Fibers OCPSF pfas pfas pfas 2 pfas 15 EPA 2021 7 26 4 EPA 15 2021 10 14 11 23 71 OCPSF ACC pfas pfas E PA Environmental Working Group EPA OCPSF pfas pfas 5 15 pfas National Association of Clean Water Agencies (NACWA) E PA 15 pfas E PA 15 Preliminary Effluent Guidelines Program Plan 15 ACC NACWA 4 EPA Announces Intent to Bolster Limits on Water Pollution from Power Plants 5 pfas Dan Kildee 4 6 pfas 2021 9 21 2022 2021 10 2022 9 National Defense Authorization Act NDAA 4350 pfas pfas pfas pfas 2020 2021

5 pfas PFOA PFOS PFOA PFOS 2020 8 2021 1 9 21 ACC 18 pfas pfas 9 22 23 2022 10 1 11 22 11 19 cloture 84/100 4350 National Defense Authorization Act for Fiscal Year 2022 Statement of Administration Policy ACC - National Defense Authorization Act for Fiscal Year 2022 EPA pfas 2021 10 18 E PA pfas pfas 2021 2024 EPA pfas E PA pfas 7 pfas 3 pfas pfas pfas pfas pfas Safe Water Drinking Act SDWA Clean Water Act CWA Comprehensive Environmental Response, Compensation.

6 And Liability Act CERCLA Clean Air Act CAA TSCA EPA E PA pfas pfas 2023 F DA 3 pfas 1 2021 11 15 Infrastructure Investment and Jobs Act pfas 100 EPA pfas Strategic Roadmap: EPA's Commitments to Action 2021-2024 pfas FACT SHEET: Biden- Harris Administration Launches Plan to Combat pfas Pollution 2021 10 18 FACT SHEET: President Biden s Bipartisan Infrastructure Law Advances Economic and Public Health Opportunities for Tribal Communities 2021 11 18 EPA pfas GenX 2021 10 25 E PA pfas GenX GenX 2021 10 18 EPA pfas GenX 2009 PFOA PFOA GenX PFOA GenX EPA GenX GenX 8 GenX EPA GenX RfD Reference Dose RfD EPA RfD RfD EPA GenX RfD RfD RfD

7 3 10-6 mg/kg/day g/kg/day RfD 3 10-5 mg/kg/day g/kg/day PFOA PFOS PFBS RfD EPA PFOA PFOS RfD PFOA PFOS RfD EPA GenX Human Health Toxicity Assessments for GenX Chemicals EPA GenX Human Health Toxicity Values for Hexafluoropropylene Oxide (HFPO) Dimer Acid and Its Ammonium Salt Also Known as GenX Chemicals EPA PFOA PFOS 2021 11 16 EPA EPA PFOA PFOS 4 PFOA PFOS EPA PFOA PFOS 1 National Primary Drinking Water Regulations EPA PFOA PFOS PFOA EPA EPA Advances Science to Protect the Public from PFOA and PFOS in Drinking Water 2021 11 16 PFOA PFOS Drinking Water Health Advisories for PFOA and PFOS 1 National Primary Drinking Water Regulations 1-2.

8 C9-C14 PFCA REACH XVII 2021 8 4 9 14 C9-9 C14 PFCA REACH XVII EU 2021/1297 2023 2 25 C9-C14 PFCA C9-C14 PFCA 25ppb C9-C14 PFACE 260ppb EU 2021/1297 amending Annex XVII to Regulation (EC) No 1907/2006 of the European Parliament and of the Council as regards perfluorocarboxylic acids containing 9 to 14 carbon atoms in the chain ECHA SVHC 2021 9 3 ECHA REACH 26 Substances of Very High Concern SVHC 4 ECHA REACH XV SVHC 2021 10 18 26 SVHC ( )-1,7,7-trimethyl-3-[(4-methylphenyl)met hylene]bicyclo[ ]heptan-2-one covering any of the individual isomers and/or combinations thereof (4-MBC) 6,6'-di-tert-butyl-2,2'-methylenedi-p-cr esol (DBMC) S-(tricyclo[ '2,6]deca-3-en-8(or 9)-yl) O-(isopropyl or isobutyl or 2-ethylhexyl) O-(isopropyl or isobutyl or 2-ethylhexyl) phosphorodithioate tris(2-methoxyethoxy)vinylsilane ( )-1,7,7-trimethyl-3-[(4-methylphenyl)met hylene]bicyclo[ ]heptan-2-one covering any of the individual isomers and/or combinations thereof (4-MBC)

9 ECHA SVHC 2021 10 22 EU Ecolabel 1992 2021 10 8 3,000 pfas CMR SVHC 2027 12 31 2024 10 Clean and Circular economy: Commission extends EU Ecolabel to all cosmetics and pet-care -cosmetics-and-pet-care-2021-10_en