Extended-infusion piperacillin/tazobactam (Zosyn ...

1 Extended-infusion piperacillin/tazobactam (Zosyn ). compatibility reference IV (Y-site) Drug-Incompatibility Dataa Incompatible drugs Variable Compatibility AVOID Y-site administration with Zosyn . Acyclovir Ganciclovir Cisatracuriumc Amiodarone HCL gemcitabine Amphotericin B Haloperidol Vancomycind Caspofungin Hydroxyzine Chlorpromazine Idarubicin Cisplatin Mitomycin Daunorubicin Mitoxantrone Decarbazine Nalbuphine Dobutamine Prochlorperazine Doxorubicin Promethazine Doxycycline Streptozocin Droperidol Tobramycinb Famotidine a Table lists known Y-site incompatibilities with pip/tazo, for all other agents, refer to Micromedex for compatibility information b Avoid mixing aminoglycosides & penicillin in the same bag and avoid infusing concurrently through same line c Compatibility is concentration dependent, call pharmacy for assistance d Compatibility of vancomycin and piperacillin/tazobactam is concentration and formulation dependent.

2 Recommend to avoid infusing vancomycin and zosyn through the same lumen concurrently if possible ( administer vancomycin and zosyn infusion through separate lumens or try administering vancomycin prior to the zosyn 4-hour infusion). For additional information or clarification, call pharmacy. IV (Y-site) Infusion Solution-Compatibility Data Infusion solution Compatible? Sodium chloride Yes Dextrose 5% Yes Bacteriostatic water for injection Yes (benzoyl alcohol or parabens). Lactated Ringers (LR) Injection Yes Bacteriostatic sodium chloride for injection Yes (benzoyl alcohol or parabens). Adapted from Trissel, Handbook on Injectable Drugs16th Edition. Bethesda, Maryland: American Society of Health-System Pharmacist, 2011. Print