Form 603 - asx.com.au

1 To:Company Name/SchemeSirtex Medical 078 166 1221. Details of substantial holderNameMacquarie Group Limited ('MQG'); andits controlled bodies corporate listed in Annexure A('Macquarie Group Entities')ABN/ACN/ARSN (if applicable)122 169 279 The holder became a substantial holder on:5 July 20182. Details of voting powerThe total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in on the date the substantial holder became a substantial holder are as follows:Class of securitiesNumber of securitiesPerson's votesVoting power 'FPO'3. Details of relevant interestsThe nature of the relevant interest the substantial holder or an associate had in the following voting securities on the date thesubstantial holder became a substantial holder are as follows:Number of securitiesClassFPOFPO4.

2 Details of present registered holdersThe persons registered as holders of the securities referred to in paragraph 3 above are as follows:Number of securitiesClassFPOFPOFPOFPO5. ConsiderationThe consideration paid for each relevant interest referred to in paragraph 3 above, and acquired in the four months prior to the day that the substantial holder became a substantial holder is as follows:Holder of relevant interestDate of acquisitionConsideration Number of securitiesClassSee Annexure B6. AssociatesThe reasons the persons named in paragraph 3 above are associates of the substantial holder are as follows:Name and ACN (if applicable)Nature of associationMacquarie Group Limited & Controlled Bodies CorporateMacquarie Group Entities7. AddressesThe addresses of persons named in this form are as follows.

3 MACQUARIE SECURITIES AUSTRALIA LTDP rint name Dennis LeongCapacityCompany SecretarySign hereDate10 July 2018 Level 6, 50 Martin Place, Sydney NSW 2000, AustraliaSignature MACQUARIE INVESTMENT MANAGEMENT AUSTRALIA LTD Northern Trust Corporation (Singapore Branch)Northern Trust Corporation (Singapore Branch) 307,099 Macquarie Group LimitedLevel 6, 50 Martin Place, Sydney NSW 2000, AustraliaMACQUARIE INVESTMENT MANAGEMENT AUSTRALIA LTDL evel 6, 50 Martin Place, Sydney NSW 2000, AustraliaMACQUARIE BANK LIMITEDL evel 6, 50 Martin Place, Sydney NSW 2000, AustraliaMACQUARIE INVESTMENT MANAGEMENT AUSTRALIA LTD National Nominees LimitedNameAddressMACQUARIE INVESTMENT MANAGEMENT AUSTRALIA LTDMACQUARIE BANK LIMITEDMACQUARIE BANK LIMITEDMACQUARIE BANK LIMITED3,103,312 Form 603 Corporations Act 2001 Section 671 BMACQUARIE INVESTMENT MANAGEMENT AUSTRALIA LTDP ursuant to section 608 of the Corporations Act415.

4 147 Holder of relevant interestRegistered holder of securitiesPerson entitled to be registered as holderHolder of relevant interestNature of relevant interestMACQUARIE BANK LIMITEDBond Street Custodians LimitedBond Street Custodians Limited98,109 National Nominees Limited9,939 Pursuant to section 608 of the Corporations Act3,103,312 Notice of initial substantial holder3,518,4593,518, personal use onlyANNEXURE 'A'This is the annexure marked A of 17 pages referred to in the Notice of initial substantial LeongCompany Secretary, Macquarie Group Limited10 July 2018 Controlled Bodies CorporateACN / Company No Entity Name Incorp Country 136 024 136 024 970 PTY LTDA ustralia154 402 154 402 927 Pty LtdAustralia0113-01-020216 ACACIA RENEWABLES SOLAR POWER CO.

5 , , Republic of153 275 677 ACN 153 275 677 Pty LtdAustralia69930570 Adagia 421 805 ADL SOFTWARE PTY LTDA ustralia9783406 Aerospace Finance 6771 UK LimitedUnited Kingdom09812041 Aerospace Finance 6816 UK LimitedUnited Kingdom9819666 Aerospace Finance 6818 UK LimitedUnited KingdomHRB 237758 AIF Business Solutions GmbHGermany595997 Alchemy Telco Solutions LimitedIrelandAlster & Thames Partners (USA) LLCU nited StatesArbor Village Property Owner LLCU nited States20-3690322 AVENAL POWER CENTER, LLCU nited StatesBattery Storage Holdings, LLCU nited States008604966 BELIKE NOMINEES PTY. LIMITEDA ustraliaBella Holdings LLCU nited StatesBella Property Owner LLCU nited States11431362 Bing TK Holdings LimitedUnited Kingdom11431590 Bing TK LimitedUnited Kingdom126708 Bing TK Topco LimitedJersey20-2937246 Blue Grass Abstract LLCU nited States46-5587770 Blueshine, LLCU nited StatesBluestone Equity Release Series 1 Warehouse TrustAustralia30-0746347 Boketo LLCU nited States008607065 BOND STREET CUSTODIANS LIMITEDA ustralia008606924 BOND STREET INVESTMENTS PTY.

6 LIMITEDA ustralia004680004 BOSTON AUSTRALIA PTY LIMITEDA ustralia005008702 BOSTON LEASING PTY. LIMITEDA ustralia88217 Bunhill Investments UnlimitedJersey002865830 BUTTONWOOD NOMINEES PTY LIMITEDA ustralia0689555875 Cafasso Investco BVBAB elgiumCanadian Breaks Holdings, LLCU nited StatesCanadian Breaks II LLCU nited States26-5600465 CANADIAN BREAKS LLCU nited StatesCanadian Breaks SponsorCo, LLCU nited States04800336 Capital Meters Holdings LimitedUnited Kingdom04800317 Capital Meters LimitedUnited KingdomCBP Holdings LLCU nited States11425435 Chablis TK Holdings LimitedUnited Kingdom10974030 CHAPTRE GreenCo Holdings LimitedUnited Kingdom06373185 Cheeryble Developments LimitedUnited Kingdom46527C1/GBLCHINA PROPERTY INVESTMENTS LIMITEDM auritius20-2937258 Closing Documentation Services, LLCU nited StatesCMC Holdco StatesCMC Railroad.

7 States30-0791081 Colorado - PTH, LLCU nited StatesCER151028DM3 Comercializadora Energia de la Reforma S. de de and Industry Brokerage StatesConnecticut Mystic Lien, LLCU nited States03241012 Corona Energy LimitedUnited Kingdom03241002 Corona Energy Retail 1 LimitedUnited KingdomSC138299 Corona Energy Retail 2 LimitedUnited Kingdom02746961 Corona Energy Retail 3 LimitedUnited Kingdom02798334 Corona Energy Retail 4 LimitedUnited Kingdom07545410 Corona Energy Retail 5 LimitedUnited Kingdom02879748 Corona Gas Management LimitedUnited Kingdom51-0566317 Crystal Screens Media States82-3700769CT MLH Bluff Road Venture, LLCU nited States64075C1/GBLDALIAN II HOLDING COMPANY LIMITEDM auritius11110550 Dalmatia WtE EUR Holdings LimitedUnited Kingdom2 For personal use only11108831 Dalmatia WtE EUR Topco LimitedUnited Kingdom10520639 Danube Investments LimitedUnited Kingdom37-1737048DC - PTH, LLCU nited States23-3061021 Delaware Capital ManagementUnited States27-1291359 Delaware Capital Management Advisers, States23-2226487 Delaware Distributors, States23-2791871 Delaware Distributors, States46-3152566 Delaware Emerging Market Debt FundUnited States46-4850078 Delaware Investments Advisers Partner, StatesN/ADelaware Investments Corporate Bond Fund (UCITs)

8 Ireland46-4639812 Delaware Investments Distribution Partner, States46-1906107 Delaware Investments Fund AdvisersUnited States46-5056965 Delaware Investments Fund Services CompanyUnited StatesDelaware Investments Global Value Equity (UCITs)Ireland9670677 HDelaware Investments Global Value Equity Fund (UCITs)Ireland13-3465352 Delaware Investments Management Company, LLCU nited States23-2859589 Delaware Management CompanyUnited States23-2601407 Delaware Management Trust CompanyUnited States13-3465338 Delaware Service Company, States81-2626999 Delaware Small Cap Growth FundUnited StatesDELTA1 FINANCE TRUSTA ustralia083 158 614 DIVCO 22 PTY LIMITEDA ustraliaEast Inwood Arbor, LLCU nited States608 027 505 EDUWEST EQUITY HOLDING PTY LIMITEDA ustralia608 027 434 EDUWEST PROJECT CO PTY LIMITEDA ustralia608 027 596 EDUWEST PROJECT HOLDING COMPANY PTY LIMITEDA ustralia127338827 ELAINE WINDFARM PTY LTDA ustraliaElectrodes Holdings.

9 LLCU nited States069344001 ELISE NOMINEES PTY LIMITEDA ustraliaSC546822 Energetics Asset Management UK LimitedUnited KingdomSC234695 Energetics Design & Build LimitedUnited KingdomSC234694 Energetics Electricity LimitedUnited KingdomSC303150 Energetics Gas LimitedUnited KingdomSC455073 Energetics Holdco LimitedUnited KingdomSC573458 Energetics Meters LimitedUnited KingdomSC455134 Energetics Midco LimitedUnited KingdomSC293480 Energetics Networked Energy LimitedUnited KingdomSC546714 Energetics Networks UK LimitedUnited KingdomSC455074 Energetics Topco LimitedUnited Kingdom0200-03-009420 ENERGY PRATHAM COMPANY LIMITEDK orea, Republic of006435810 EQUITAS NOMINEES PTY. LIMITEDA ustraliaERC Holdco LLCU nited States627002886 ESSENTIAL SHIPCO 1 PTY LIMITEDA ustralia627003696 ESSENTIAL SHIPCO 2 PTY LIMITEDA ustralia627003703 ESSENTIAL SHIPCO 3 PTY LIMITEDA ustralia627003712 ESSENTIAL SHIPCO 4 PTY LIMITEDA ustralia627003007 ESSENTIAL SHIPCO 5 PTY LIMITEDA ustralia079878783 EURO FIN CO PTY LTDA ustralia11246622 Euro II PPP Platform GP LimitedUnited Kingdom11246816 Euro II PPP Platform LP LimitedUnited Kingdom11254324 Euro III Platform Partner LimitedUnited Kingdom11246941 Euro III PPP Platform GP LimitedUnited Kingdom619687 Euro Investco PPP Ireland GP LimitedIreland11171693 Euro PPP Platform GP LimitedUnited Kingdom11171914 Euro PPP Platform LP LimitedUnited Kingdom20-5600465 FAS 1 LLCU nited States137357 FINCH

10 SECURITIES LIMITEDC ayman Islands12-377-980/0001-25 FIP Gestora de Recursos - PTH 1, LLCU nited States36-4767568FL - PTH 10, LLCU nited States90-1004919FL - PTH 2, LLCU nited States61-1718024FL - PTH 3, LLCU nited States80-0941771FL - PTH 4, LLCU nited States90-1005859FL - PTH 5, LLCU nited States80-0942248FL - PTH 6, LLCU nited States90-1006383FL - PTH 7, LLCU nited States80-0942772FL - PTH 8, LLCU nited States80-0943053FL - PTH 9, LLCU nited States46-2260160 Florida Coral Lien Investments, LLCU nited States61-1577729 Florida Dundee Lien Investments, LLCU nited States10662385 Forth SPV 1 LimitedUnited Kingdom10662568 Forth SPV 2 LimitedUnited Kingdom95-4881110 Four Corners Capital Management, LLCU nited StatesFox-Pitt Kelton Cochran Caronia Waller (USA) LLCU nited States06-1058201 Fox-Pitt Kelton Cochran Caronia Waller LLCU nited States3 For personal use only01601171 Fox-Pitt, Kelton LimitedUnited Kingdom32157 Fox-Pitt, Kelton Capital I CIP GP LimitedJersey20-5600465 Fremantle Energy Holdings, LLCU nited States20-5600465 Fremantle Energy, LLCU nited States20-2384759 Fremantle Wind Holdings States9699834 Fulfilment Services LimitedUnited Kingdom106204862 FUNDCORP PTY LIMITEDA ustraliaFusion Management Holdings, LLCU nited StatesFusion Property Holdings, LLCU nited States08921103 Fuujin Power LimitedUnited Kingdom30-0790149GA - PTH, LLCU nited States054001400 GATESUN PTY.