frequency. Keeping a headache What is in this leaflet

1 NEW ZEALAND CONSUMER MEDICINE INFORMATION. rizamelt . Rizatriptan benzoate orodispersible tablets 5 mg & 10 mg in the mouth, and that patients do frequency. Keeping a headache What is in this leaflet not require a drink to swallow the diary will help you identify and tablet with. monitor all of the possible migraine This leaflet answers some common triggers you encounter. Once the questions about rizamelt . A migraine attack is caused by the triggers are identified, you and your blood vessels in the brain doctor can modify your treatment It does not contain all the available widening/dilating which results in and lifestyle appropriately. information. It does not take the the throbbing, painful headache . place of talking to your doctor or Ask your doctor if you have any pharmacist. rizamelt works by reducing the questions about why this dilated blood vessels in the brain to medicine has been prescribed for All medicines have risks and their normal size and therefore you.

2 Benefits. Your doctor has weighed helps to relieve the pain. It also Your doctor may have prescribed it the risks of you taking rizamelt blocks the release of certain for another reason. against the benefits they expect it chemicals from nerve endings that will have for you. cause more pain and other This medicine is available only with symptoms of migraine. a doctor's prescription. If you have any concerns about taking this medicine, ask your Migraine attacks last anything from doctor or pharmacist. two hours to two days and they can Before you take return frequently. The severity and Keep this leaflet with the frequency of migraine attacks may rizamelt . medicine. You may need to read it vary. again. When you must not take Migraine occurs in about one out of every 10 people. It is three times it What rizamelt is more common in women than men. Six out of ten migraine sufferers Do not take rizamelt if : used for have their first attack before the age You have an allergy to any medicine containing of 20.

3 Rizatriptan benzoate or any rizamelt is used to treat of the ingredients listed at headache pain and other symptoms There is no single cause of migraine. It tends to run in families. the end of this leaflet . associated with migraine attacks. It does not work for other types of Certain things, singly or in combination, can trigger migraine Some of the symptoms of an headaches. attacks in some people. Some of allergic reaction may include: these triggers are: shortness of breath; wheezing or A Migraine is an intense, throbbing, difficulty breathing; swelling of the typically one-sided headache . It face, lips, tongue or other parts of often includes nausea, vomiting, certain foods or drinks, for the body; rash, itching or hives on sensitivity to light, and sensitivity to example, cheese and other the skin. sound. Some people may have dairy products, chocolate, visual symptoms before the citrus fruit, caffeine, alcohol (especially red wine) Do not take rizamelt if : headache , called an aura.

4 An aura can include flashing lights or wavy stress, anger, worry You are currently taking a lines. changes in routine, monoamine oxidase under or over sleeping, inhibitor (MAOI) medicine, rizamelt contains the active change in diet, missing or have used a MAOI in the ingredient rizatriptan benzoate. It meals last two weeks. belongs to a group of medicines bright light or loud noises called 5-HT1BD/1D receptor agonists hormonal changes in Do not take rizamelt if : (also known as serotonin receptor women, during agonists). menstrual periods. You have high blood pressure that is not being rizamelt is an orodispersible treated If you understand what triggers your tablet. This means the tablet is attacks, you may be able to prevent You have heart disease or designed to dissolve on the tongue, migraine attacks or reduce their a heart condition including Page 1 of 4. angina or have had a Tell your doctor if you have or inhibitors (SSRIs) used to previous heart attack have had any of the following treat depression You have had a stroke or medical conditions: Venlafaxine and duloxetine transient ischaemic attack which are SNRIs serotonin (TIA) High blood pressure norepinephrine reuptake You have peripheral Diabetes inhibitors used to treat vascular disease, including Smoking depression.

5 (but not limited to) A high cholesterol level St John's Wort a medicinal ischaemic bowel disease. A family history of heart herb used to treat disease. depression. Ask your doctor if you are unsure if you have or have had any of the Tell your doctor if you suffer from These medicines may be affected above medical conditions. Phenylketonuria (PKU) as by rizamelt or may affect how rizamelt contains phenylalanine well it works. You may need Do not take this medicine if you which is a component of aspartame. different amounts of your medicines are pregnant unless you discuss or need to take different medicines. the risks and benefits with your Tell your doctor if you are Sometimes the timing of taking the doctor first. It has not been pregnant or plan to become medicines is all that is needed to adequately studied for use in pregnant or are breast-feeding. ensure they do not interact.

6 Pregnancy. Your doctor can discuss with you the risks and benefits involved. Your doctor and pharmacist have Do not breast-feed if you are more information on medicines to taking this medicine. If you have not told your doctor be careful with or avoid whilst taking It is not known whether rizatriptan, about any of the above, tell this medicine. the active ingredient in rizamelt him/her before you start taking passes into breast milk. rizamelt . How to take Do not give this medicine to children under the age of 18. Taking other medicines rizamelt . years. Tell your doctor or pharmacist if Safety and effectiveness of you are taking any other Follow all directions given to you rizamelt in children under 18 medicines, including any that you by your doctor or pharmacist years have not been established. get without a prescription from carefully. your pharmacy, supermarket or They may differ from the information Do not take this medicine after health food shop.

7 Contained in this leaflet . the expiry date printed on the pack or if the packaging is torn or Some medicines should NOT be If you do not understand the shows signs of tampering. taken with rizamelt . These instructions on the box, ask your If it has expired or is damaged, include: doctor or pharmacist for help. return it to your pharmacist for disposal. Monoamine oxidase inhibitors How much to take (MAOIs) for depression such If you are not sure whether you as moclobemide, phenelzine The usual dosage is one 10 mg should start taking this medicine, tranylcypromine and rizamelt orodispersible tablet. talk to your doctor. pargyline Reduction of the headache pain to mild or none can occur within 30. Sumatriptan, a similar minutes. Before you start to take medicine which is also used to treat migraine. it If the first orodispersible tablet DOES help your migraine but the Tell your doctor if: Some medicines and rizamelt .

8 Migraine comes back later, you may may interfere with each other. take another tablet. Take the You have allergies to any These include: second tablet at least two hours other medicines, foods, after the first. Do not take more than preservatives or dyes Propanolol, a medicine used 3 orodispersible tablets (30 mg) in Your headache is more to treat high blood pressure any 24 hour period. severe than your usual Ergotamine, another type of migraine, or it behaves medicine used to treat If the first orodispersible tablet differently migraine DOES NOT help your migraine, do You have basilar migraines Methysergide, a medicine not take another tablet for the same or hemiplegic migraines used to treat migraine migraine attack as it is unlikely to You have any other medical Sertraline, paroxetine, help. It is still likely though that conditions. citalopram, escitalopram or rizamelt will help during your fluoxetine, which are next attack.

9 Selective serotonin re-uptake Page 2 of 4. You should NOT take the 10 mg and pharmacist that you are taking Tell your doctor if you have any rizamelt orodispersible tablet rizamelt . of the following side effects and whilst you are taking propranolol. they worry you: Tell any other doctors, dentists, and How to take rizamelt pharmacists who treat you that you Difficulty working because of: are taking this medicine. rizamelt orodispersible tablets sleepiness, tiredness are packaged in blister packs. Do If you are going to have surgery, tell dizziness not remove the tablet from the the surgeon or anaesthetist that you nervousness blister pack until just prior to are taking this medicine. agitation dosing. It may affect other medicines used inability to sleep (insomnia). during surgery. decreased mental sharpness With clean, dry hands, peel the hallucinations (seeing or hearing blister pack open as indicated on If you become pregnant while taking things that are not there).

10 The pack and place the this medicine, tell your doctor orodispersible tablet on the tongue. immediately. Stomach and bowel problems: It will dissolve on the tongue in the mouth and be swallowed with the nausea and vomiting If your headache is more severe saliva. It is not necessary to take stomach upset or pain than your usual' migraine, tell your rizamelt orodispersible tablets diarrhoea. doctor. with liquid. Changes to your sight or taste: Things you must not do dry mouth Do not give your medicine to thirst anyone else, even if they have bad taste the same condition as you. blurred vision. Step 1 Step 2. Skin problems: Things to be careful of hot flushes or sweating Be careful driving or operating redness or flushing of face machinery until you know how skin rash, itching. rizamelt affects you. Step 3 Step 4 This medicine may cause dizziness, Other side effects: light-headedness, drowsiness, in muscle weakness It does not matter if you take some people.