Guidelines for Endpoints in Animal Study Proposals
Guidelines for Endpoints in Animal Study Proposals Introduction Study endpoints are a part of every Animal Study Proposal (ASP) and the Animal Care and Use Committee ... A plan for the following animal care and monitoring procedures: a. Animals involved in experiments that may lead to moribundity or death will be monitored at least .
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Guidelines for Standards of Care in Animal Shelters
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oacu.oir.nih.govpregnant dam should ensure rapid cerebral anoxia to the fetus with minimal disturbance to the uterine milieu minimizing fetal arousal.7 Methods for euthanasia of the dam should follow recommendations of the ARAC Guidelines for Euthanasia of Rodents Using Carbon Dioxide and the AVMA Guideline for the Euthanasia of Animals.
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Administration Routes - OACU
oacu.oir.nih.govMice & Rats -Intramuscular Injection (IM) IM injections are administered in the thigh muscles of the hind limb. Caution must be used to avoid injury to the sciatic nerve, which is located in close proximity to the femur. 1. Restrain the animal by grasping the skin along its back with your left hand (if right-handed). 2.
INTRAVENOUS INJECTION (IV) - National Institutes of Health
oacu.oir.nih.govINTRAVENOUS INJECTION (IV) IV injections are administered to rabbits in the . marginal ear vein. The picture below illustrates the location of the vein. 1. Place animal in appropriate restraint device. 2. Shave the hair over the marginal ear vein. 3. Clean injection site with alcohol. 4. Insert a small bore (22 – 30 gauge) needle with a ...
Injection Routes, Maximum Needle Sizes & Volumes
oacu.oir.nih.govInjection Subcutaneous Injection Mouse. Skin Volume: <0.05ml Needle: <25 Gauge Rear Leg/Thigh Volume: <0.05ml Needle: <23 Gauge Abdomen - Lower Quadrant Volume: <2-3ml Needle: <21 Gauge Lateral Tail Vein Volume: <0.2ml …
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