HUMALOG MIX25 and MIX50 - Medsafe

1 HUMALOG , . HUMALOG MIX25 and HUMALOG MIX50 . CARTRIDGES. Insulin Lispro (rbe). Consumer Medicine Information What is in this leaflet means that the action of HUMALOG . MIX25 is prolonged. This leaflet is designed to provide HUMALOG MIX50 is 50% insulin you with answers to some common What the HUMALOG lispro and 50% insulin lispro questions about these medicines. It insulins are used for protamine suspension. This means does not contain all the available that the action of HUMALOG . HUMALOG insulins are used to information and does not take the MIX50 is prolonged. reduce high blood sugar (glucose). place of talking with your doctor. The duration of effect of levels in insulin dependent diabetic The information in this leaflet was patients. Diabetes is a condition in HUMALOG insulins varies in each last updated on the date shown on the which your pancreas does not individual and also depends on dose, final page.

2 More recent information produce enough insulin to control site of injection, blood supply, body on this medicine may be available. your blood sugar level. Extra insulin temperature and physical activity. Make sure you speak to your is therefore needed. This medicine is available only with pharmacist, nurse or doctor to obtain a doctor's prescription. There are two types of diabetes the most up to date information on mellitus: this medicine. You can also download the most up to date leaflet Type 1 diabetes - also called Insulin from The updated Dependent Diabetes Mellitus (IDDM). Patients with type 1. Before using leaflet may contain important information about HUMALOG and diabetes always need insulin to HUMALOG insulins its use that you should be aware of. control their blood sugar levels.

3 Tell your doctor if you have any of All medicines have risks and Type 2 diabetes - also called Non the following conditions or if you benefits. Your doctor has more insulin dependent diabetes mellitus have ever experienced any of these information about these medicines (NIDDM). Some patients with type 2 conditions. than is contained in this leaflet. Also, diabetes may also need insulin after your doctor has had the benefit of initial treatment with diet, exercise When you must not use the taking a full and detailed history and tablets. HUMALOG insulins from you and is in the best position HUMALOG insulins are insulin to make an expert judgement to meet Do not use/inject HUMALOG . lispro, which works more quickly your individual needs. insulins: than soluble human insulin because If you have any concerns about the insulin molecule has been if you have had an allergic using these medicines, talk to your changed slightly.

4 Reaction to HUMALOG , doctor or pharmacist. HUMALOG MIX25 or HUMALOG MIX25 is 25% insulin HUMALOG MIX50 , or to any Keep this leaflet with your lispro and 75% insulin lispro of the ingredients listed at the medicine. protamine sulfate suspension. This end of this leaflet (see 'Product You may need to read it again. Description'). HUMALOG CARTRIDGES 1. Signs of an allergic reaction if you are pregnant or intend to Taking other medicines include redness, swelling and become pregnant. Tell your doctor if you are taking itching at the injection site, rash, Pregnancy may make managing any other medicines, including any shortness of breath, fast pulse or your diabetes more difficult. that you buy without a sweating. Insulin needs usually decrease prescription from your pharmacy, if the packaging is torn or during the first three months of supermarket or health food shop.

5 Shows signs of tampering. pregnancy and increase during Some medicines may affect the way if you are experiencing low the last six months. your HUMALOG insulin works. blood sugar (hypoglycaemia). if you are breast-feeding or These include: if HUMALOG solution is plan to breast-feed. oral antidiabetic medicines cloudy, thickened, coloured or It is not known if HUMALOG is medicines that affect your has solid pieces in it. excreted in significant amounts in metabolism (corticosteroids such if HUMALOG MIX25 or breast milk. as prednisone, cortisone). HUMALOG MIX50 suspension if you often have medicines used for oral is no longer cloudy white after hypoglycaemia (low blood contraception gentle shaking or if it has solid sugar) or if you have trouble pieces in it. recognising the symptoms of medicines used in thyroid hypoglycaemia.

6 Replacement therapy if the cartridge appears frosted. Under certain conditions the early certain antibiotics used to treat This can occur when solid white warning signs of hypoglycaemia tuberculosis, such as isoniazid particles stick to the bottom and walls. can be different or less medicines such as aspirin or other pronounced. salicylates if the expiry date (EXP) on the pack has passed. if you drink alcohol. certain medicines used to treat HUMALOG MIX25 or if you are ill. depression HUMALOG MIX50 should not be Illness, especially with nausea certain medicines used to treat given intravenously. and vomiting, may cause your asthma, such as salbutamol or insulin needs to change. Even if terbutaline The use of HUMALOG MIX25 and HUMALOG MIX50 has not been you are not eating, you still medicines used to treat high studied in children under the age of require insulin.

7 You and your blood pressure or other heart 18. doctor should design an insulin conditions plan for those times when you are HUMALOG MIX25 or certain medicines used to treat sick. HUMALOG MIX50 should not be people with growth disorders and used in an insulin infusion pump. if you are exercising more than tumours, such as octreotide usual. If you are not sure whether you medicines used to treat hormone- should start using HUMALOG Exercise may lower your need for related disorders, such as danazol insulin. Exercise may also speed insulins, talk to your doctor or thiazolidinediones (TZDs), also pharmacist. up the effect of an insulin dose, used to treat type 2 diabetes;. especially if the exercise involves when used with insulin there may Before you start using the area of injection site ( the be an increased risk of fluid HUMALOG insulins leg should not be used for retention and heart disease.)

8 Injection just prior to running). You must tell your doctor: Discuss with your doctor how Your doctor or pharmacist has more if you have had an allergic much insulin you should use if information on medicines to be reaction to any medicine which you are exercising. careful with or avoid while using HUMALOG insulins. you have used previously to if your diet changes. treat your current condition. Tell your doctor about these Changes in diet may cause your if you have or have had any medicines before you use insulin needs to change. HUMALOG insulins. medical conditions, especially Tell your doctor about these things kidney, liver or heart disease. before you use HUMALOG . if you experience fluid retention insulins. especially in the hands, ankles or feet. HUMALOG CARTRIDGES 2. How to use HUMALOG Preparing a dose important to ensure the correct dose is injected.

9 Insulins 1. Check your cartridge. The solution of HUMALOG should 4. Only after seeing a stream of Follow all directions given to you be clear and colourless. The insulin at the needle tip can you by your doctor or pharmacist suspension in HUMALOG proceed to dial up your required carefully. MIX25 , HUMALOG MIX50 dose. There may still be some These may differ from the cartridges should be white and small air bubbles left in the information contained in this leaflet. cloudy or milky. cartridge. These are harmless, but if the air bubble is too big, it may Your doctor may tell you to use 2. HUMALOG MIX25 and make the dose of your injection HUMALOG with a longer acting HUMALOG MIX50 cartridges less accurate. human insulin such as HUMULIN must be rolled between the NPH. A Consumer Medicine palms ten times and inverted Injecting a dose Information leaflet is also available ten times until the contents are for this product, ask your pharmacist.

10 Uniformly mixed. Do not shake 1. Wash your hands. vigorously as this may cause 2. Choose a site for injection. Use of There may be a delay in the effect of frothing which may interfere injection sites should be rotated HUMALOG when it is mixed with with the correct measurement so that the same site is not used HUMULIN NPH, compared to of the dose. more than approximately once a HUMALOG and HUMULIN NPH. being injected separately. 3. Inspect the cartridge for uniform month mixing and repeat the above steps 3. Remove outer needle cap. HUMALOG should not be mixed if necessary. with any other animal or human 4. Stabilise the skin by spreading it insulin preparations. If HUMALOG MIX25 or or pinching up a large area. Insert HUMALOG MIX50 cartridges the needle as instructed by your How much to use appear "frosted", please return to the doctor.