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c. this creates strain in the ring, since it is a four membered ring d. b-lactam becomes good acylating agent for active site serine of penicillin binding protein (see later) 2. Carboxylate a. Negatively charged at neutral pH b. Anchors drug in active site pocket (positively charged) 3. Acylamido side chain a. Necessary for biological potency b.

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ETIZOLAM (Trade Names: Etilaam, Etizest, Depas, Etizola ...

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fused to a seven-membered 1,4diazepine ring. Etizolam also contains a fused triazolo ring. A 2-chlorophenyl ring is attached at the 4-position and an ethyl group is attached at the 2-position of the thienodiazepine ring structure. Etizolam has a molecular formula of C17H15ClN4S and a molecular weight of 342.8 g/mol. The structure

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