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Interim analysis: The alpha spending function approach

In this case, the Pocock critical value for all interim analyses is 2.41. For O'Brien-Fleming, the constant is 244 so the critical values correspond to 2-04 ,/(5/k). Note that for the final analysis, where K = 5, the critical value is 2.04 which is close to the nominal 0.05 critical value of 1.96.

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