Investment Case

1 1. Investment Case Seventh Replenishment 2022. 2 The Global Fund Fight For What Counts 2022 3 The Global Fund Fight For What Counts 2022. Contents At least US$18 billion for the Global Fund's Seventh Replenishment would save 20 million Executive Summary 4. lives, cut the death rate 1. State of the Fight Against HIV, Tuberculosis and Malaria 18. from HIV, TB and 2. Twenty Years of Impact 32 malaria by 64% and 3. Fighting Pandemics and Building a Healthier and More Equitable World 42. build a healthier, 4. Strengthening Health Systems for Resilience, more equitable world. Sustainability and Pandemic Preparedness 50.

2 5. The Global Fund Needs at Least US$18 Billion 60 Cover: Safi Ouango and her 2-year-old daughter Oudima Aoulaiou, who received seasonal malaria chemoprevention (SMC), a preventive malaria treatment. Conclusion 82 Using various safety precautions, the SMC program in Burkina Faso continued Annexes 86 to be rolled out during the COVID-19. pandemic in order to protect gains made in the fight against malaria. Glossary 102 The Global Fund/Olympia de Maismont 4 The Global Fund Fight For What Counts 2022 5 The Global Fund Fight For What Counts 2022. Executive In 2002, in an act of extraordinary global solidarity and leadership, the world came together to create Summary the Global Fund to fight what were then the deadliest pandemics confronting humanity: HIV and AIDS, tuberculosis (TB) and malaria.

3 Over the 20 years that followed, this This is the moment for the world and facilitate the emergence of unique partnership has invested more to recommit to protect everyone from new diseases. Changes in rainfall, than US$53 billion, saving 44 million the deadliest infectious diseases. temperature and humidity are already lives and reducing the combined death That means protecting people across shifting malaria transmission into new rate from the three diseases by more the world, whoever they are and areas. Climate change will also alter than half in the countries in which the wherever they live, from the earlier TB and HIV through, for example, the Global Fund invests.

4 Pandemics we have yet to defeat HIV, forced displacement or migration of TB and malaria; the pandemic running vulnerable populations and increased Behind these huge numbers lie a rampant right now COVID-19; and economic insecurity. Moreover, climate multitude of individual human stories. future pandemics we have yet to see change and other environmental The 44 million people whose lives but know will come. pressures will also change the This is the moment have been saved include parents who care for their children, employers and workers that build thriving economies, Protecting the world from such pandemics is not an impossible dream.

5 Dynamics of zoonotic spillover, the process by which diseases affecting animals transition to humans. Since for the world to neighbors and friends that contribute to their communities. They are children who have survived malaria or have been With science, money and leadership, we have proven we can fight and beat even the most formidable infectious three-quarters of new disease threats originate in animals, any increase in zoonotic spillover will increase the recommit to protect protected from HIV and are now young adults. They are community leaders who strive every day to make the lives disease threats.

6 Yet neither will it be easy. Since no one is safe from infectious diseases until everyone is probability of new pandemic threats. The Global Fund's Seventh everyone from the of people in their communities better, healthier, and longer. Every life saved and every infection averted has safe, protecting us all from pandemics will take a truly global effort. Because preventing, detecting and responding Replenishment is the world's opportunity to rise to the challenge and take bold action. We can deadliest infectious a multiplier effect. In 2022, we need another such moment to pandemics requires much more comprehensive and effective systems and capacities, we need to step up turbocharge progress in the fight against HIV, TB and malaria, regaining ground lost during the pandemic and diseases.

7 Of global solidarity and leadership. COVID-19 continues to cause huge loss of life, human suffering and Investment in the critical components of health systems and tackle barriers to access. The communities most getting back on track toward finally ending these three pandemics by 2030. We can also deliver a step change in economic and social disruption across affected by pandemics, particularly pandemic preparedness, strengthening the world. Hard-won gains against HIV, those most marginalized, must be at the overall resilience of systems for TB and malaria are being reversed, the center, voicing their needs and health by investing in their capacities with devastating consequences for designing responses that truly leave to prevent, detect and respond to new the poorest and most vulnerable no one behind.

8 Health threats. By taking an integrated communities. The entire United Nations approach to the pursuit of these two Sustainable Development Goals agenda Climate change and environmental complementary objectives, we can is now at risk, as inequities deepen, damage make this all the more maximize the impact of every dollar. poverty spirals and social and political urgent. Climate change will affect the tensions grow. epidemiology of existing diseases 6 The Global Fund Fight For What Counts 2022 7 The Global Fund Fight For What Counts 2022. The impact The imperative of COVID-19 of investing on HIV, TB in systems and malaria for health Strong, inclusive systems for health are the most effective way to defeat HIV, TB.

9 Even before COVID-19, progress against surge in the number of undiagnosed Twenty years of experience in fighting Trained, equipped, appropriately paid and malaria and HIV, TB and malaria was off track. and untreated cases. The number of the deadliest infectious diseases and protected health workers, whether That's why, during the Global Fund's people treated for drug-resistant TB have taught us that investing in doctors, nurses, laboratory technicians strengthen global Sixth Replenishment three years ago, dropped by 19%, while treatment for the critical components of health or community health workers, are the ir- health security.

10 We called on the world to step up the people with extensively drug-resistant systems, such as laboratory networks, replaceable components of an effective fight. The response from donors was a TB fell by 37%. Overall, the number trained health workers and supply and resilient health system. Investing resounding yes : We raised a record- of people being treated for TB fell chains, is an essential complement to in health and community systems, and breaking US$14 billion, enough to by over 1 million. Malaria deaths and disease-specific interventions such specifically in pandemic preparedness, enable a significant increase in funding cases increased significantly in 2020, as insecticide-treated mosquito nets is above all about making smart and for HIV, TB and malaria programs and mainly due to COVID-19 disruptions.