日本における主要な臨床検査項目 ... - jccls.org

1 1 2014/03/31 4/7 2 3 IFCC

2 WG 2011 2012 jccls 2012 6 WG 40 1 4 4 - CBC 10 3 6 9 12 /L / L 5 - SI 6 (1) (2) (3)

3 2005 IFCC 2009 [1],[2] [3] [4] 40 2012 reference individual reference value 95% reference interval 2 7 m s m ( ) 95% ( 3)

4 [5] 1) BMI 28 2) 75g 3) >20 4) 5) 1 6) 2 7) HBV, HCV, HIV 4) 8 (*1) 95 ( 1) BMI<25 1 30 (1) 3 (2) (3) 10 7 10 20 (1) LD CK AST (3)

5 20 30 5~10 [6] 8793 6345 2 IFCC [1,2] 40 (8) RBC, Hb, Ht, WBC, PLT, MCV, MCH, MCHC (6) : (TP), (ALB), (UN), (CRE), (UA), (TB) (4) (TG), (TC), HDL (HDL-C), LDL (LDL-C) (8) AST, ALT, LD, ALP, GT, CK, (ChE), (AMY) (6) Na, K, Cl, Ca, (IP), (Fe) (2) (GLU), HbA1c (6) CRP, (IgG, IgA, IgM), (C3, C4) CBC 8 TP ALB TB 9 calibrator 6 [5], [7] (1).

6 ALB, GLB, UA, TG, TC, HDL-C, LDL-C, AST, ALT, LD, GT, CK, CRP 2 (2) : BMI 26 ( ) 25 g/ (3) : MCV 85 fL (4) : ( ) 3 95 [5] 10 SDR 3 [5]

7 4 1 SDR SDR 5 4 45 *2 2 6 6 5 50 95 ( 2) 50 ALP, TC, LH, FSH 40~52 45 2 11 1 12 GT U/L 2 13 SDR 10 (SD) SD 1/4 SD (SDR) SDR [1], [5] 3 SDR SDR 45 SDR 14 A [8] BA ( ) BA(%) A (2)

8 15 45 SDR 16 CBC calibrator [9] 95 LDL-C 139mg/dL 7mg/dL LDL-C.

9 17 [1] Ichihara K, Ceriotti F, Tam TH, et al., The Asian project for collaborative derivation of reference intervals: (1) strategy and major results of standardized analytes. Clin Chem Lab Med 2013, 2013;51:1429 42. [2] Ichihara K, Ceriotti F, Mori K, et al., The Asian project for collaborative derivation of reference intervals: (2) results of non-standardized analytes and transference of reference intervals to the participating laboratories on the basis of cross-comparison of test results.

10 Clin Chem Lab Med 2013 ;51:1443 57. [3] Yamamoto Y, Hosogaya S, Osawa S, Ichihara K, et al., Nationwide multicenter study aimed at the establishment of common reference intervals for standardized clinical laboratory tests in Japan. Clin Chem Lab Med 2013 ;51: 1663 72. [4] Kinoshita S, Toyofuku M, Hamasaki N, et al., Standardization of Laboratory Data and Establishment of Reference Intervals in the Fukuoka Prefecture: A Japanese Perspective. CIin Chem Lab Med 2001;39:256-26 [5] Ichihara K, Boyd J. An appraisal of statistical procedures used in derivation of reference intervals. Clin Chem Lab Med 2010; 48:1537-51 [6] . 2011 [7] . 2005; 49:1471-85 [8] 36 2006 ; 35:144-153 [9].