July 2011 - bioMerieux

1 Mass Spectrometry Pg 2 VITEK 2 Pg 3 Henry Ford Hospital Pg 5 ProLab Pg 6 New VITEK 2 Cards Pg 8 Total AST Pg 11 Events Calendar Pg 12 july 2011IN THIS ISSUE:2 Mass Spectrometry: Cutting Edge microbial IdentificationNedal Safwat, US Clinical Marketing ManagerbioM rieux, , NC The rapid identification of microorganisms has been a major obstacle to clinicians as they struggle to provide appropriate antimicrobial treatment while waiting sometimes days for adefinitive identification of the pathogen. Now, a new method has emerged that can reduce identification to a few minutes. Mass Spectrometry (MS) is a technique used to screen simultaneously a multitude of molecules and determine their identity by analyzing their individual mass-to-charge ratio. These molecular signatures can be used for rapid bacterial and fungal identification (ID) from isolated colonies. The use of mass spectrometry for bacterial ID promises to be particularly suitable and cost-efficient for laboratories with high volumes of samples.

2 But the big payoff for clinicians is the huge reduction in the time it takes to identify organisms. Specifically, mass spectrometry enables laboratories to rapidly identify organisms from colonies grown overnight. This technology may also assist clinical microbiologists in facing the ever-increasing number of potentially pathogenic species of bacteria and fungi. A modern identification system such as MS, coupled with a flexible database that can be easily updated and expanded, can meet this growing challenge. What does MALDI-TOF stand for?MALDI-TOF stands for Matrix Assisted Laser Desorption/Ionization Time Of Flight. It describes the way a sample isconverted into charged particles, or ionized, and what method has been used to separate the different mass particles after charging. A spectrum is produced by measuring and plotting the different mass of the Future bioM rieux is moving quickly to provide an integrated solution to this emerging technology through a partnership agreement with Shimadzu, a pioneer in the development of MALDI-TOF MS technology, and by acquiring a comprehensive microbial mass spectra database from AnagnosTec, a primary innovator in MALDI-TOF MS microbial identification .

3 For microbiologists who choose mass spectrometry for microbial ID, bioM rieux is developing integrated workflow solutions with its VITEK 2range to ensure optimal user convenience, full sample traceability and quality of results. All of bioM rieux s systems will be managed with the new MYLA Web-based middleware solution, commercialized in early 2011 . The fully integrated system will provide rich connectivity, enhanced information and workflow management.* Research Use Only - Not for use in diagnostic rieux Connection july 20113 Microbiology laboratories are struggling with challenges that impede their ability to complete their work in a timely manner. Loss of skilled labor, increasing pressure to deliver more rapid results and coping with increasing workloads create issues that take time to resolve. This highlights the need for increased productivity by eliminating inefficient steps in our day-to-day rieux s new software release for the VITEK 2 PC has features designed to help you become more efficient by saving you steps and saving you time.

4 New VITEK 2 Software Release: A Major Leap ForwardNedal Safwat, Clinical Marketing ManagerbioM rieux, , NC This new software release has an optional feature which allows users to access the VITEK 2 PC remotely to view and validate results. Avoid walking from one location to AnotherThese wasted steps can be taken back through remote access to the VITEK 2 PC reportingImpaired workflow process allows users to recapture timepreviously spent walking results from one location to another and to verify results on their own time. Improved Review of Inconsistent ResultsSome laboratories have access to a microbiology expert, but this person may not always be available to examine inconsistent results remote access, multiple users can log into the VITEK 2 computer from anywhere on their laboratory network. Up to 10 users may access the computer remotely at the same time. This will help increase productivity of the testing process, eliminate the need to waste steps going back and forth to check results and allows the opportunity to accomplish tasks within normal working hours.

5 Common tasks include: View and approve patient isolates in the isolate view View VITEK 2 Advanced Expert SystemTM (AES) configuration Resolve AES conflicts Validate results which bioART has stopped for reviewIf you are interested in capitalizing on the benefits of remote multi-user access, please contact your local bioM rieux sales intelligence simplifies workflow bioART is bioM rieux s Advanced Reporting Tool which allows users to: Create antibiotic suppression rules Hold isolates for review Create customized comments or instructions for each organism situationbioART ensures quality reporting through predefined rules, such as product limitations or FDA Indications For Use, and allows creation of custom rules to ensure compliance with your institution s policies and rules are created easily and may be constructed by using the MIC value, interpretation, card type, organism, patient location, patient physician, phenotype, specimen source, specimen type or test results.

6 BioART was designed to be easy to use and to help you save time through efficient processing and validation of organisms tailored to the needs of your Diagnostics & Services VILINKTMG atewayFIREWALLS imultaneous Multi-user AccessRemote Multiuser Access* Research Use Only - Not for use in diagnostic Multiple Instrument ControlThe new software also allows up to four computers to connect to the VITEK 2 PC. This may help your institution consolidate information onto one computer and reduce the footprint of the AST resultsPreliminary results may be reported when they become available before the entire AST card finishes. Preliminary card results may also be expertised by the Advanced Expert System . By providing preliminary reports to physicians, appropriate clinical decisions may be made earlier, which can have a positive impact on patient suppressionThis feature allows users to suppress an MIC when the final category call does not match the tested MIC value, as in the case of therapeutic or biological corrections.

7 This helps eliminate confusion by allowing microbiologists to suppress the MIC on the chart report in these software updates through VILINK By implementing the VILINK computer into your laboratory network you can receive incremental software updates through the Internet. If CLSI makes a change to organism breakpoints, bioM rieux can create new organism updates and provide them to you quickly through the VILINK. VILINK is bioM rieux s secure solution for remote monitoring and troubleshooting of your VITEK 2 instrument. The VILINK gateway computer allows bioM rieux customer support to resolve issues remotely and download these software you are interested in learning more about the VILINK gateway, please contact your local bioM reiux sales QC optionWith the CLSI M50-A changes related to streamlined QC, the software contains the list of organisms for either comprehensive or streamlined QC for identification cards. Streamlined QC tests a key biochemical reaction in the ID card to ensure that no card degradation has occurred during shipment.

8 New card options Streptococci AST cardThis software update will support our Streptococci card. The new AST-ST card will be validated for most major Streptococcal pathogens including S. pneumonia, S. agalactiae, S. pyogenes and a host of other clinically significant isolate information The VITEK 2 Systems software will now be able to receive a downloaded organism identification and beta-lactamase result from a Laboratory Information System (LIS) or OBSERVA . The downloaded organism identification will automatically link with the AST card when the accession number matches. If the organism identification is not an organism claimed by the AST card, then the organism field will not be populated. There is a new button in the View and Maintain Isolate Results screen that will allow access to the organism identification and beta-lactamase result downloaded from the software programs have become essential tools that improve the analysis of test results and detection of resistant organisms.

9 Is such a tool: This new release is a major leap forward in software-controlled, automated identification and susceptibility instrumentation. A wide range of new features has been added to help you save steps and time. 5bioM rieux Connection july 2011 Robert G. Fowler, MT, (ASCP), CLSH enry Ford HospitalDetroit, MIRobert G. Fowler, senior lead technologist at the 800-bedHenry Ford Hospital in Detroit always considered the VITEK 2 the workhorse of the hospital s microbiology lab. It s hard to improve a device that already turns around pathogen antibiotic susceptibility results in less than eight hours, said Fowler. But the new upgrade, installed late last year at Henry Ford, has made Fowler a believer that eventhe best instruments can improve. Someone in the lab compared the VITEK 2 with the upgrade to jumping directly to a smart phone from a rotary dial phone, and I think that s a very appropriate description, Fowler two VITEK 2 units at Henry Ford always have been central to the lab s antibiotic panels and infectious disease susceptibility testing including microbial identification with bacteria and yeast identification (ID), antibiotic susceptibility testing (AST) and resistance mechanism detection as well asepidemiologic trending and reporting.

10 However, the old interface presented some challenges for a machine that performs up to 200 tests per day from samples taken at the main hospital and satellite hospitals. According to Fowler, the old roll and scroll interface could make it time-consuming to find specific results. Since there was just a single PC in the lab to interface with the two VITEK 2 units, there was often a line of lab scientists waiting to get to their of Use and FlexibilityWith the GUI (Graphic User Interface), working with VITEK 2 has gotten a lot easier and more intuitive. The interface is less text heavy and more graphical, including windows, icons and various menus and buttons allowing the staff at the Henry Ford microbiology lab to find and categorize samples by patients or ID type. The automated software generates a list of unusual patterns for review. The Advanced Expert System (AES) findings, the ART (Antibiotic Resistance Transferability) comments, the analysis messages and the results are all on the same window so branching to other areas such as from the AES findings to the phenotypic graphical display is just a point and click, Fowlersaid.