Minimum PPE Required Hazardous Drug List

1 Minimum PPE RequiredHandling only - No alterationContained Crush/Split Crush/Splitabacavir (susp) (2)ziagen/epzicom/trizivirgenotoxic/carc inogenicLowabacavir (tablet) (2)ziagen/epzicom/trizivirgenotoxic/carc inogenicUniversalLowModerateacitretin (capsule) (3)soriataneteratgogenic/reproductiveUni versalModerateanastrazole (tablet) (1)arimidexantineoplasticLowModerateHigh android (capsule) (3)methyltestosteroneteratogenic/reprodu ctiveUniversalModerateapomorphine (inj sq) (2)apomorphinegenotoxicModeratearthotec/ cytotec (tablet) (3) diclofenac/misoprostolteratogenic/reprod uctiveUniversalLowModerateastagraf XL (capsule) (2)tacrolimuscarcinogenic/teratogenicUni versaldo not openavordart (capsule) (3)dutasterideteratogenic/reproductiveUn iversalModerateazathioprine (tablet) (2)apomorphinecarcinogenicUniversalLowMo deratebicalutamide (tablet) (1)casodexantineoplasticLowModerateHighb risdelle (capsule) (3)paroxetineteratogenic/reproductiveUni versalModeratecaprelsa (tablet) (1)vandetanibantineoplasticLowcarbamazep ine (suspension) (2)tegretolteratgogenic/carcinogenicLowc arbamazepine (tablet) (2)

2 Tegretolteratgogenic/carcinogenicUnivers alLowModeratecarbamazepine ER (tablet) (2)carbatrol/equatrolteratgogenic/carcin ogenicUniversalclonazepam (tablet) (3)Klonopinteratogenic/reproductiveUnive rsalLowModerateclonazepam ODT (tablet) (3)Klonopinteratogenic/reproductiveUnive rsalcolchicine (capsule) (3)colchicineteratogenic/reproductiveUni versalModeratecolcrys (tablet) (3)colchicineteratogenic/reproductiveUni versalLowModeratecrizotinib (capsule) (1)xalkoriantineoplasticLowdo not opencyclophosphamide (capsule) (1)cyclophosphamideantineoplasticLowHigh cyclophosphamide (tablet) (1)cyclophosphamideantineoplasticLowMode rateHighcyclosporin (solution) (2)sandimmune/neoral /gengrafcarcinogenicLowcyclosporine (capsule) (2)sandimmune/neoral /gengrafcarcinogenicUniversalModeratecyc losporine (eye drops) (2)restasiscarcinogenicLowdivalproex (tablet) (2)depakoteteratogenic/reproductiveUnive rsalHazardous drug ListTablet Minimum PPE requiredMinimum PPE Required Open CapsuleMinimum PPE requireddo not split/crushdo not split/ crushdo not split/ crushdo not split/ crushThis document s purpose is only to provide general guidance.

3 It is not a definitive interpretation for how to comply with DOSH requirements. Consult the actual NIOSH Hazardous drugs list and program regulations in entirety to understand all specific compliance (for facility QA) Minimum PPE RequiredHazardous ToxicityMinimum PPE Required Other drug NameDispensed/Common drug Name (Formulation) and (NIOSH CATEGORY #)Additional InformationUniversal (Green) - handling and disposed of using normal precautions. Low (Yellow) - handle at all times with gloves and appropriate engineering controls.

4 Moderate (Orange) -handle at all times with gloves, gown, eye and face protection (with splash potential) and appropirate engineering controls. High (Red) - double gloves, gown, eye and face protection in addition to any necessary engineering ER (tablet) (2)depakote erteratogenic/reproductiveUniversaldival proex sprinkle (capsule) (2)depakote sprinklesteratogenic/reproductiveUnivers alModerateella (tablet) (3) ulipristalteratogenic/reproductiveUniver salLow Moderateemcyt (capsule) (1)estramustineantineoplasticLowHighestr adiol (tablet) (2)estradiolcarcinogenic/teratogenicUniv ersalLowModerateestradiol (transdermal) (2)estradiolcarcinogenic/teratogenicLowe strogen, conjugated (cream) (2)

5 Premarincarcinogenic/teratogenicLowestro gen, conjugated (tablet) (2)premarin, prem-procarcinogenic/teratogenicUniversa lestrogen/progesterone (patch) (2)climara, combipatchcarcinogenic/teratogenicLowest ropipate (tablet) (2)ogencarcinogenic/teratogenicUniversal Low Moderateetoposide (capsule) (1)toposarantineoplasticLowHighexemestan e (tablet) (1)aromasinantineoplasticLowModerateHigh fareston (tablet) (1)toremifeneantineoplasticLowModerateHi ghferriprox (tablet) (2)deferiproneteratogenicUniversalLow Moderatefluconazole (injectable) (3)diflucanteratogenic/reproductiveHigho nly if reproductive risk - if not, universalfluconazole (tablet) (3)diflucanteratogenic/reproductiveUnive rsalLow Moderatefluorouracil (cream/solution) (1)adrucil/carac/efudex /fluoroplexantineoplasticModeratechemo rated glovesfluoxymesterone (tablet) (2) fluoxymesteronecarcinogenic/teratogenicU niversalLow Moderateflutamide (capsule) (1)flutamideantineoplasticLowHighfosphen ytoin (Inj-IM) (2)cerebyxteratogenicModeratefosphenytoi n (Inj-IV) (2)cerebyxteratogenicHighganciclovir (Inj) (2)cytovenecarcinogenic/teratogenicHighg eodon (injection) (3)

6 ZiprasidonereproductiveModerategilenya (capsule) (2)fingolimodcarcinogenic/teratogenicUni versalModerategleevac (tablet) (1)imatinibantineoplasticLowhexalen (capsule) (1)altretamineantineoplasticLowHighhydro xyurea (capsule) (1)droxia/hydreaantineoplasticLowHighica tibant (syringe/sq) (3)firazyrteratogenic/reproductiveModera teonly if reproductive risk - if not, universaljalyn (capsule) (3) dutasteride/tamsulosinteratogenic/reprod uctiveUniversalModeratelamuvudine/zidovu dine (tablet) (2) combivir carcinogenicUniversalLowModerateleflunom ide (tablet) (2)aravacarcinogenic/teratogenicUniversa lletairis (tablet) (3) ambrisentanteratogenic/reproductiveUnive rsalletrozole (tablet) (1)femaraantineoplasticLowModerateHighle ukeran (tablet) (1)chlorambucilantineoplasticLowModerate Highleuprolide (injection) (1)lupron depot/eligard/ lupanetaantineoplasticModerate/ High (syringe/vial)lomustine (capsule) (1)gleostineantineoplasticLowHighlysodre n (tablet) (1)mitotaneantineoplasticLowmatulane (capsule) (1)procarbazineantineoplasticLowHighmedr oxyprogesterone (tablet) (2)proveracarcinogenic/teratogenicUniver salLow Moderatemegestrol (susp) (1)

7 MegaceantineoplasticModeratemegestrol (tablet) (1)megaceantineoplasticLowModerateHighme lphalan (tablet) (1)alkeranantineoplasticLowModerateHighd o not split/crushdo not split/crushdo not split/ crushdo not split/crushdo not split/ crushdo not split/ crushmercaptopurine (susp) (1)purinetholantineoplasticModeratemerca ptopurine (tablet) (1)purinetholantineoplasticLowModerateHi ghmethotrexate (tablet) (1)rheumatrexantineoplasticLowModerateHi ghmethylergonovine (tablet) (3)methylergonovinereproductiveUniversal LowModeratemultaq (tablet) (3)dronedaroneteratogenic/reproductiveUn iversalLow Moderatemycophenolate (tablet) (2)cellceptcarcinogenic/teratogenicUnive rsalmycophenolic acid (pwd/recon) (2)mycophenolic acidcarcinogenic/teratogenicModeratemyle ran (tablet) (1)busulfanantineoplasticLowModerateHigh nevirapine (tablet) (2)viramunecarcinogenicUniversalLowModer atenevirapine ER (tablet) (2)viramune XRcarcinogenicUniversalnevirapine Susp (tablet) (2)viramunecarcinogenicLownexavar (tablet) (1)sorafenibantineoplasticLowModerateHig hoxcarbazepine (susp) (2)trileptalcarcinogenicLowoxcarbazepine (tablet) (2)

8 TrileptalcarcinogenicUniversalLowModerat eoxcarbazepine ER (tablet) (2)oxtellar XRcarcinogenicUniversalpanretin (topical) (3) alitretinointeratogenic/reproductiveLowp aroxetine (tablet) (3)paxil/pexevateratogenic/reproductiveU niversalLow Moderatepaxil (suspension) (3)paroxetineteratogenic/reproductiveLow paxil CR (tablet) (3)paroxetineteratogenic/reproductiveUni versalphenoxybenzamine (capsule) (2)dibenzylinecarcinogenicUniversalmoder atephenytoin (suspension) (2)dilantincarcinogenic/teratogenicLowph enytoin (tablet) (2)dilantincarcinogenic/teratogenicUnive rsalLowModeratephenytoin ER (capsule) (2)dilantin/phenytekcarcinogenic/teratog enicUniversaldo not openprogesterone (capsule) (2) prometriumcarcinogenicUniversaldo not openprogesterone (intravaginal) (2) first progest carcinogenicLowpropylthiouracil (tablet) (2)propylthiouracilcarcinogenic/teratoge nicUniversalLowModeratepropylthiouracil (tablet) (2)propecia/proscarcarcinogenic/teratoge nicUniversalLow Moderatequdexy XR (capsule) (3)topiramateteratogenic/reproductiveUni versalModerateraloxifene (tablet) (2)

9 Evistacarcinogenic/teratogenicUniversalr apamune (solution) (2)sirolimuscarcinogenic/teratogenicLowr ebetol (solution) (3)ribavirinteratogenic/reproductiveLowr evlimid (capsule) (2) lenalidomideteratogenicUniversaldo not openribavirin (capsule) (3)Universaldo not openribavirin (tablet) (3)Universalrisperdal (solution) (2)risperidoneteratogenicLowrisperdal consta (injection) (2)risperidoneteratogenicModeraterisperd al M (dissolve tablet) (2)risperidoneteratogenicUniversalrisper idone (tablet) (2)risperdal teratogenicUniversalLowModeratesabril (pwd packet) (3) vigabatrinteratogenic/reproductiveModera tesabril (tablet) (3)