조스타박스 - 한국MSD

1 631 1/9 ( ) 1 ( ) : ( ) ----------------------------------- 19400 PFU ( : Oka/Merck , : MRC-5) ( ): ---------------------------------------- --------------------------------- mg ( ): ---------------------------------------- --------------- mg ( ): ---------------------------------------- ------------------------------ mg ( ): ---------------------------------------- ------------------------ mg ( ): L- ---------------------------------------- ------ mg ( ): ---------------------------------------- --------------------------- mg : ---------------------------------------- ------------ mg : ---------------------------------------- ------------------ mg ( ) : ---------------------------------------- --------------------------- mL : 1 ---------------------------------------- ---------------------- 2 ( x 16 mm, x 25 mm 1 ) 50 1 mL , ( ).

2 - .. mL . , 30 .. 631 2/9 1. 1) 2) / ( ). , . 3) : , / , HIV/AIDS (2. ), . 4) (2. ), /.

3 5) 6) (5. 1) ) 2. 50 , 32,000 . 1) 50 59 ( zostavax Efficacy and Safety Trial, ZEST) (ZEST) (n=11,184) (n=11,212) 1 . , 1 ( ) . (ZEST) 1 42 . 1% 1 . ( , ). 1. (ZEST) 1% ( 1 42 ) (N=11,094) (N=11,116) % % 631 3/9 1 5.

4 2) 60 (Shingles Prevention Study, SPS) (SPS) 38,546 (n=19,270) (n=19,276) 1 . , 2 ( , ) 3 ( ;Goodpasture's syndrome, , ) . (SPS) ( n=3,345, n=3,271) 0 42 . 1% 2 . ( 48%, 17%). 2. (SPS) 1% ( 0 42 ) (N=3,345) (N=3,271) % % / 0 4.

5 1% . ( ), ( ), ( ), ( ), ( ), ( ), ( ), ( ) , . 3) - 631 4/9 (ZEST) 42 - - 34 ( 19 , 15 ). (Polymerase Chain Reaction, PCR) 24 PCR , 10 ( 3 , 7 ) - (Varicella-Zoster Virus) , - Oka/Merck . - (n=124, 69 55 ) PCR 23 - 1 , ( Oka/Merck ).

6 (SPS) 42 - - 17 , 36 (p= ), PCR 41 PCR , 25 ( 5 , 20 ) - , - Oka/Merck . - (n=59) PCR 10 - . , ( ) 42 17 - - . 10 PCR - 2 Oka/Merck . 4) 50 (SPS) . 50-59 60 . 2 . , 60 98 1 42 2 ; 2 1.

7 50 100 , , (SPS) . - 2 ( 30 27 ), , 27 2 . - - .. 5) . , . 631 5/9 : : , : ; ; ; : : : ( ) : - ( ) : , 6) - 4 769 , (132 /769 , 229 ) , (116 /769 , 204 ) , (66 /769 , 66 ), (48 /769 , 48 ), (37 /769 , 37 ), (22 /769 , 22 ), (5 /769 , 5 ), , (4 /769 , 4 ), (3 /769 , 3 ), , , (2 /769 , 2 ), , , , , , , , , (1 /769 , 1 ).

8 - (1 /769 , 1 ) , (1 /769 , 1 ) , (unlikely) .. - (28 /769 , 34 ) , , (4 /769 , 4 ), , (3 /769 , 3 ), , (2 /769 , 2 ), , , , , , , , , , , , , , , , (1 /769 , 1 ) . (12 /769 , 15 ) , (4 /769 , 4 ), (3 /769 , 3 ), (2 /769 , 2 ), , , , , , (1 /769 , 1 ) . - (1 /769 , 1 ) , (1 /769 , 1 ) , . (unlikely) .. 7).

9 , . - : , - : 3. 631 6/9 1) - . 2) 50 . 3) . 4) . 5) (Post Herpetic Neuralgia) . 6) , / (1:1000) . 7) C , . 8) , . 4 . 9) . 2 . 10).

10 - . 11) . 4. 1) . 2) - . 3) -23 , -23 , , 4 . 5. 1) . ; , 3 (1. ). 2) - . , . 6.. 7. (N=38,546) 69 ( 59-99 ). 19,270 10,378 60 69 7,629 70 79 1,263 80.