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1 1 27 CAS No. : 112-24-3 27 10 2 3,6- -1,8- LD50/LC50 1400 mg/kg GHS 5 1720 mg/kg GHS 4 GHS GHS 1B GHS 1 EU GHS C&L 13 1. LD50 LC50 2. CAS No.

2 LD50/LC50 30 International Chemical Safety Cards ICSC : IPCS [ ] [ ] CRC Handbook of Chemistry and Physics CRC, 88th, 2007-2008 CRC Merck Index Merck, 14th ed. Merck and Company, Inc ChemID : US NLM TOXNET [ ] GESTIS IFA [ ] 3 Registry of Toxic Effects of Chemical Substances RTECS : US NIOSH [ ] Hazardous Substance Data Bank HSDB : NLM TOXNET [ ] Patty's Toxicology Patty, 5th ed.

3 , 2001 : Wiley-Interscience JECDB : OECD GLP [ ] Environmental Health Criteria EHC : IPCS [ ] Concise International Chemical Assessment Documents CICAD : IPCS EHC [ ] [ ] EU Risk Assessment Report EURAR : EU [ ] Screening Information Data Set SIDS : OECD SIDS SIAR SIDS Dossier SIAR Robust Study Summary SIDS SIAP [ ] [ ] ATSDR Toxicological Profile ATSDR : US ATSDR [ ] ACGIH Documentation of the threshold limit values for chemical substances 4 ACGIH,7th ed.

4 ,2010 : ACGIH MAK Collection for Occupational Health and Safety MAK : DFG [ ] ECHA REACH Registered Substances ECHA REACH [ ] TOXLINE US NLM [ ] PubMed US NLM [ ] Google Scholar Google-S Google [ ] Google Google [ ] Ya h o o Yahoo [ ] Recomendation on the Transport of Dagerous Goods, Model Regulations TDG, 18th ed., 2013 UNECE [ ] ECHA C&L Inventory ECHA CLP [ ] 3.

5 ICSC 1 EURAR CRC 2 SIDS 9 Merck 3 EHC ChemID 4 ACGIH 5 GESTIS 5 MAK 10 RTECS 6 REACH 11 HSDB 7 JECDB Patty 8 TDG 12 ATSDR EU GHS C&L 13 CICAD Triethylenetetramine TETA , 3,6-Diazaoctane-1,8-diyldiamine, N,N'-Bis(2-aminoethyl)-1,2-ethanediamine , Trientine CAS 112-24-3 UN TDG 2259 EC Number. 203-950-6 EU Index No. 612-059-00-5 C6H18N4 1 1 GESTIS g/cm 20 C GESTIS 278 C GESTIS 12 C GESTIS 135 C closed cup GESTIS mbar 2 0 C 15 mbar 50 C GESTIS GESTIS SIDS 6 pH 10 g/L SIDS / Log P GESTIS CRC ICSC 1 mL/m = mg/m 20 C 1013 mbar GESTIS TETA 9

6 Merck LD50 LC50 2500 mg/kg 1 ChemID LD50 LC50 1600 mg/kg 2 2500 mg/kg 1 805 mg/kg 3 GESTIS LD50 LC50 2500 mg/kg 2800 mg/kg 4 805 mg/kg 3 RTECS LD50 LC50 2500 mg/kg 1 * mg/kg* 5 805 mg/kg 3 * RT ECS 7 HSDB LD50 LC50 1600 mg/kg 2 4300 mg/kg 2 Patty LD50 LC50 g/kg 3 *2 mL/kg =804 mg/kg *1 3 *2 *1 g/cm3 *2 Pa SIDS LD50 LC50 2500 mg/kg 1 1600 mg/kg 2 550 mg/kg 4 805 mg/kg 3 REACH LD50 LC50 mg/kg mg/kg mg/kg *1 6 1400 mg/kg *2 1720 mg/kg mg/kg *3 8 > 1000 < 2000 mg/kg bw *4 7 REACH CAS Amines, polyethylenepoly-, triethylenetetramine fraction CAS 90640-67-8 *1 according to EPA FR , No.

7 188, September 27, 1985 equivalent or similar to OECD Guideline 401 *2 comparable to the OECD Guideline 401 *3 according to OECD Guideline 402 *4 Method: BASF test according to and : A Method for Determining the Dermal Toxicity of Pesticides. 26, 59 (1969). PubMed [ Triethylenetetramine OR CAS Acute toxicity] PubMed 8 ICSC GESTIS 4 5 L 63 87 40% mL 9 10 9 RTECS 49 mg 10 20 mg/24H 11 490 mg 10 5

8 Mg/24H 11 HSDB 6 10% 8 5 10 8 12 Carpenter, Smyth 10 3 13 Patty 6 5 3 14 10 45 9 15 SIDS TETA EC Directive 67/584/EEC R21 REACH OECD TG 404 GLP 3 TETA 3 60 4 24 3 24 60

9 60 4 24 4 14 16 TG REACH 11 Preparation of test site shaved and abraded intact abraded OECD TG 435 60% in vitro TETA GHS B II 17 OECD TG 404 GLP 50% 25% 5% 3 60 4 24 4 50% 25% 5% 3 50% 60 0 13 6 3 4 1 14 4 6 1 25% 60 24 1/6 48 11 2/6 4 24 14 1/6 5% 72 18 19 20 TG 1 15 5 8 15 24 8 21 OECD TG 405 GLP 1 mL 1 40 80 10 10 10 20 20 70 110 1 22 BASF 2 50 L

10 24 OECD TG 405 10 1 3 8 10 24 1 48 2 48 1 24 48 72 2 3 4 8 23 PubMed [ Triethylenetetramine OR CAS & irritation] PubMed 2259 TRIETHYLENETETRAMINE Class 8 Packing group II EU GHS C&L Acute Tox. 4 * H312 Harmful in contact with skin. * mimimum classification Skin Corr. 1B H314 Causes severe skin burns and eye damage.