Transcription of OECD/OCDE - nihs.go.jp
1 OECD/OCDE 487 2010 7 22 OECD 2010 OECD OECD OECD in vitro 1. In vitro MNvit MN (1)(2) B cytoB 2 cytoB 1 (3)(4) 2.
2 MNvit in situ FISH (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)( 16) 3. 1 OECD 473 (17) MNvit 2 FISH 4.
3 MNvit in vitro 5. MNvit cytoB MNvit CHO V79 CHL/IU L5178Y (18)(19)(20)(21)(22)(23)(24)(25)(26)(27) (28)(29)(30)(31) SFTG; Soci t Fran aise de Toxicologie G n tique (18)(19)(20)(21)(22) International Workshop on Genotoxicity Testing (4)(16) EC ECVAM 487 OECD/OCDE OCDE 2010 2 ECVAM ESAC (32)(33)(34) TK6 (35) HepG2 (36)(37) (38) 6.
4 1 7. In vitro in vivo pH (39)(40)(41) pH pH 8. 1 9. 10.
5 11. (5)(19)(42)(43) CHO V79 CHL/IU L5178Y (18)(19)(20)(21)(22)(25)(26)(27)(28)(30) OECD/OCDE 487 OECD 2010 3 12.
6 18 35 (44) 13. CO2 14. 37 C 15.
7 CytoB PHA 16. 1254 (45)(46) + - (46)(47)(48)(49) S9 (50) 1254 (46)(47)(48)(49) S9 1 10% v/v S9 17. (51) 487 OECD/OCDE OCDE 2010 4 18.
8 (52)(53) 19. S9 cytoB 20. MNvit 1 cytoB (5)(54)(55) cytoB PHA 26 21.
9 CytoB cytoB 3 6 g/mL 22. pH (39)(40)(41) 23. 29 cytoB RICC RPD 2 cytoB RI 2 24. cytoB (5) OECD/OCDE 487 OECD 2010 5 25.
10 CytoB 500 CBPI (5)(26)(56) RI 2 cytoB CBPI RI 500 26. cytoB BrdU (57) in situ PI (25)(26)(27)(28) RPD RICC (16)(56)(58)(59) 2 27.
