Onset, Peak, and Duration of Common Pain Medications Table
ONSET, PEAK AND DURATION OF COMMON PAIN MEDICATIONS Medication Onset of Action (minutes)* Peak Effect (hours)* Duration of Action (hours)* Route of Admin. Comments Methadone 30 -60 1 -2 4 -6 Full analgesic effects, are not attained until 3 to 5 days after initiation of dosing. Drug is known to eliminate slowly causing high risk of overdose
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