[PDF] XDM Quad Single-Use Mixing System DATA SHEET

1 XDM quad Single-Use Mixing SystemDATA SHEETThe Xcellerex XDM quad Mixing System is designed for convenient and efficient Mixing of buffer, media, product, and other process fluids. The Single-Use System eliminates the hassle of time-consuming and costly clean-in-place (CIP), steam-in-place (SIP), and cleaning validation. The result is more efficient processing and rapid batch-to-batch turnover XDM quad is comprised of a full-featured and integrated rigid containment System complete with motor and controls, and an irradiated USP Class VI, Single-Use LDPE fluid contact layer bag equipped with a disposable bottom-mounted impeller.

2 The engagement between motor and disposable impeller is via a robust magnetic coupling, and agitation is driven through stainless steel bearings within the impeller, imparting high torque and rapid Mixing to the 1-866-XcellerexThe XDM quad Mixing System is available in 50L, 100L , 200L, 500L and 1000L sizes. Key Featuresl Powerful integrated magnetic agitator with compact VFD and AC motorl Optimized, disposable impellerl Square configuration offers enhanced Mixing efficiency through natural baffling effect. l Workable heights and low center of gravity increase level of safetyl Bottom is slanted on two planes for extremely low bag hold-up volumel Compact unit with handles and casters for ease of mobilityl Fitted square bag minimizes bag wrinklesl Real-time sensing and sampling capability via mixer window and bag probe ports.

3 Sampling port and thermowell for non-invasive temperature sensingl Integrated holders for 50ml conical buffer tubesl Bags have integrated 3 Tri-clamp port for powder additionl Translucent lid is included for protection of bag and is equipped with securing feature for bag powder addition port and hopperl 500L and 1,000L systems equipped with removable door for easy bag loadingl Two standard bag types: BASIC and PLUS (additional lines, probe ports, and con-nections)l System also available in either polypropylene, single -wall stainless steel or jacketed stainless steel (for heating and cooling applications).l Fully wash-down ratedThe System delivers flexibility with the availability of two standard bag types that include varying numbers of tubing lines and connections, and sampling and sensing capabilities to ac-commodate a wide array of applications.

4 Key features of the bag and rigid container also permit seamless transitioning between powder-liquid and liquid-liquid Mixing applications. The XDM quad Mixing System is available in either polypropylene, single -wall stainless steel or or jacketed stainless steel (for heating and cooling applications). 1-866-XcellerexXDM quad Mixers: System SPECIFICATIONSXDM quad (Polypropylene) SystemsXDM quad -S (Stainless Steel) SystemsXDM quad -T (Jacketed Stainless Steel) Systems50 Liter100 Liter200 Liter500 Liter50 Liter100 Liter200 Liter500 Liter1000 Liter50 Liter100 Liter200 Liter500 Liter1000 LiterDIMENSIONSC ontainer Interior (Inches LxWxH) x X x 20 x 2025 x 25 x 2533 x 33 x x X x 20 x 2025 x 25 x 2533 x 33 x 3341 x 41 x x x x 20 x 2025 x 25 x 2533 x 33 x 3341 x 41 x 41 Exterior (Inches LxWxH) X 27 X x 33 x x 38 x x x X X 4224 x x 37 x x x x x X X X37x x x 4238.

5 375 x x x x to Drain~ per foot Cross-Section~ per foot Cross-Section~ per foot Cross-SectionCaster Dimensions ( x W)4 x 24 x 24 x 2 Jacket L2 LWEIGHTS ystem Weight (empty)115 OF CONSTRUCTIONC ontainerPolypropylene304 Stainless Steel304 Stainless SteelInsulationNANAI nsulation is non-asbestos, chloride free and coated with Thurmalox mastic material LidAcrylicAcrylicAcrylicCastersSS / Polyurethane (Non-Marring)SS / Polyurethane (Non-Marring)SS / Polyurethane (Non-Marring)MOTOR/VFDTypeAC MotorAC MotorAC or 230V: (50/60 Hz)115V or 230V: (50/60 Hz)115V or 230V: (50/60 Hz)FunctionalityRun/Stop, Forward/Break/ReverseRun/Stop, Forward/Break/ReverseRun/Stop, Forward/Break/ReversePower Cord10 is IP66, CE Certified/Drive is IP65 NEMA 4X, CE CertifiedMotor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE CertifiedMotor is IP66, CE Certified/Drive is IP65 NEMA 4X, CE CertifiedAll specifications are subject to change without quad OPTIONS & ACCESSORIESThe following options are available for all XDM quad Mixing Systems.

6 U Dual pH/Conductivity Monitoring Systemu pH probeu Conductivity probeu RTD probeu Probe sheath assembliesu Level indication (floor scale or load cells for stainless steel units)u Temperature Control Unit for heating and cooling of jacketed stainless steel systemsNOTE: All probes and instrumentation are GMP 1-866-XcellerexBAg ASSEMBlY DETAIlSXDM quad Mixing Systems are available with two standard bag assembly types: BASIC and PLUSSINglE-USE BAg SPECIFICATIONSBASIC BAg ASSEMBlYPlUS BAg ASSEMBlYPortDescription50L100L200L500L10 00L50L100L200L500L1000 LAFill Port: 3 inch tri-clamp powder addition port, capped BC-flex tubing, 4 with clamp, plugged (ID indicated) inch inch inch inch inch inch inch inch inch inchC ID C-flex tubing, 4 with clamp, female MPX connector, pluggedNANANANANA DSample Line: 1/8 ID sample line with clamp, and luer lock connectionNANANANANA E, FProbe Port: Female Kleenpack Connector port for probe connectionNANANANANA FFemale Kleenpack Connector port for probe connectionNANANANANA GThermowell: for non-invasive temperature sensingNANANANANA HSample Line.

7 1/8 ID sample line with clamp, and luer lock connection IHarvest/Drain: C-flex tubing, 6 with clamp, plugged (ID indicated) inch inch inch inch inch inch inch inch inch inchSINglE-USE BAg SPECIFICATIONS50 liter100 liter200 liter500 liter1000 literDIMENSIONSD imensions (inches LxWxH) x x x 20 x 1925 x 25 x 2433 x 33 x 3241 x 41 x 37 VOlUMEM aximum55L125 L246 L571 L1019 LNominal50L100 L200 L500 L1000 LMinimum (Mix)17 L28 L44 L76 L117 LHold Up<20ml< 20 mL< 20 mL< 20 mL< 20 mLFIlMFluid Contact LayerLDPE (USP Class VI) PRESSURE RATINgMaximum, operating2 psi, 1 psiIMPEllER# of Blade Height x x Blade Pitch57 Material of ConstructionMolded HDPE impeller with 316 SS bearingTEMPERATURE RANgE2 60 CPOWDER PORTD imensions3 TCSTERIlIZATIONG amma IrradiatedThe XDM quad disposable impeller assembly is welded to the bottom of the specifications are subject to change without 1-866-XcellerexXDM quad MIXER System DETAIlSuvwyu Motor controller (fully wash down rated)v Convenient buffer tube holders (4)w AC motor and magnetic drive (fully wash down rated)x Handles for ease of mobility y Notches for supporting bag tubing (polypro.)

8 Units)z Probe port window and support bar for (A) pH/Conductivity, (B) inline sampling, and (C) of probe port window and support bar for inline sampling and sensing, such as pH, conductivity and temperature.{|~{ Removable lid with integrated support for powder addition port and hopper | Hopper and 3-inch triclamp for easy powder addition} Removable door for easy bag installation and removal (500L and 1000L only)~ Mixer bottom is slanted on two planes toward drain for minimal holdup volume; Magnetic impeller drive is easily accessible}zABxC0%20%40%60%80%100%020406 080100 Minutes% Dissolved75% Corn Syrup, 274 cp85% Corn Syrup, 561 cp90% Corn Syrup, 1000 cp1% NaCL in Corn Syrup, XDM200 The XDM quad demonstrates effective Mixing even at high viscosities6g/L NaCL, XDM500 The XDM quad demonstrates rapid Mixing of common salt 1.

9 01 1 . 5060120180240300 Time (seconds)Conductivity (mS/cm)APPlICATIONS AND PERFORMANCE DATADMEM/F-12 Medium, XDM500 1-866-XcellerexThe XDM quad demonstrates effective Mixing of common cell culture DMEM/F-12 Medium Mixing StudyGlucose & L-Gln Trends012345678910060120180240300 Mix Time (Seconds)Component ConcentrationL-Gln (mmol/L)Glucose (g/L)XDM500 DMEM/F-12 Medium Mixing StudySodium Trend01020304050607080901000601201802403 00 Mix Time (Seconds)Component Concentration [mmol/L]Na+ (mmol/L)XDM500 DMEM/F-12 Medium Mixing StudyPotassium Trend012345678910060120180240300 Mix Time (Seconds)Component Concentration [mmol/L]K+ (mmol/L)XDM500 DMEM/F-12 Medium Mixing StudyOsmo Trend05010015020025030035040006012018024 0300 Mix Time (Seconds)[mOsm/kg]Osmo (mOsm/kg)

10 VIDEO DEMONSTRATION Base & Acid Addition / Phenolphthalein Dye Test, XDM500 A video demonstration of this Mixing test is available at TRENDOSMOlaRITy TRENDPOTaSSIUM TRENDGlUcOSE & l-GlN TRENDSu Buffer and Media Prepu pH adjustmentsu Resuspensionu Chromatography poolingu Viral inactivationu UF/DFu Formulationu Product MixingXDM quad APPlICATIONSuProduct CodeSizeType888-014150 LBasic888-035150 LPlus888-0164100 LBasic888-0154100 LPlus888-0165200 LBasic888-0155200 LPlus888-0166500 LBasic888-0156500 LPlus888-01671,000 LBasic888-01571,000 LPlusAsk about our made-to-order bags for quad Bag Assembly Ordering CodesXcellerex, Inc. Toll Free: 1-866-Xcellerex170 Locke Drive Tel: 508-480-9235 Marlborough, MA 01752 rev.