Pfizer South Africa

1 Pfizer South AfricaOur PurposeAt Pfizer , we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of healthcare products. Our global portfolio includes medicines and vaccines as well as many of the world s best-known consumer healthcare products. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world s premier innovative biopharmaceutical companies, we collaborate with healthcare providers, governments and local communities to support and expand access to reliable, affordable healthcare around the world.

2 For more than 150 years, Pfizer has worked to make a difference for all who rely on believe that to be truly healthy, it takes more than medication. This is why Pfizer South Africa is a healthcare company that s dedicated to helping South Africans live healthier lives. When you have your health, you cando whatever is a priority to you don t, you can t. What I love about being part ofPfizer is that it s always on our mind. Jennifer PowerCOUNTRY MANAGER3 These business units are underpinned by Enabling Functions that advance all of the company s businesses, organisations and priorities (such as Legal, Regulatory, HR, Business Technology, Finance and Public Affairs). Pfizer Innovative Health (PIH) is committed to discovering, developing, manufacturing and delivering innovative products and vaccines that change the outcome of chronic conditions and devastating PIH portfolio includes existing treatments and the development of new treatments in the following therapy areas: Inflammation & Immunology Metabolic Disease & Cardiovascular Risk Neuroscience & Pain Oncology Rare Diseases VaccinesPfizer Essential Health (PEH) combines the history of industry leadership, comprehensive knowledge of global healthcare markets, and a vast portfolio of trusted, quality medicines to benefit patients around the world at virtually every stage of life.

3 The PEH portfolio includes medicines that treat patients for a variety of acute and chronic conditions across many therapeutic areas, including many critical medicines and sterile injectables: Anti-Infectives & Sedation Women s and Men s Health Cardiovascular Disease Neuroscience PainPfizer Consumer Health (PCH) develops, manufactures and markets leading non-prescription medicines, low risk medical devices (for external use) and health products (mainly supplements).Our Business Our commercialbusiness is dividedinto three BusinessUnits, each of which broadly work indifferent areas of Business Units are: Pfizer Innovative Health (PIH), Pfizer Essential Health (PEH), andPfizer Consumer Health (PCH). We have a culture of ownership and excellence, and empower our colleagues to achieve beyond their expectations within an open and inclusive environment.

4 We focus intensely on colleague development and a joint commitment to excellence. We are working to drive transformation and contribute to socio-economic advancement via a holistic empowerment strategy aligned to the B-BBEE Act and Codes of Good Practice. Our Culture and ValuesWe own and live our values to deliver on customer expectations, and together make Pfizer a wonderful place at which to for PeopleCustomer FocusCollaborationLeadershipPerformanceC ommunityQuality I would like people to think about Pfizer not as a building or a logo or a corporation, but rather as a collective of individuals who are passionate about what they come to work to do every single day which is to help bring therapies to people that significantly improve their lives. Jennifer PowerCOUNTRY MANAGERthe the s discuss one JERKSIMPACTTRUSTS eize opportunities to think differently, take risks, try something and drive long-term, aligned strategies that advance our mission and shape the corrosive, self-serving and mean-spirited behaviors: it s everyone s on commitments with speed, decisiveness, and in candid and constructive debate to ensure each other s success.

5 It s time forstraight Worldwide5 CardiovascularInflammationGastroenterolo gyHaematologyBiosimilarsMetabolicDisease OncologyInfectiousDiseasesOncology &Inflammation VaccinesPfizer Worldwide175 Markets64 Manufacturing Sites134 Logistics Centres200+ Supply Partners24 500+ SKUs40+Technologies / Platforms150years300+ Employees850+ Major Product GroupsTherapeutic / Disease Areas Being Studied 9 200+ New R&D Collaborations20+ Clinical Trials75 Trial CentresOne of SA s Top 5 American Employers9 700+ Employees100 Different Prescription ProductsShare Product and Disease Knowledge with 4000+ Healthcare ProfessionalsPfizer Southern AfricaOpens in Brooklyn, New York as a fine chemical businessWorld s largest producer of penicillinProduction of citric acid puts Pfizer on the mapBecomes a publically traded company184919441880s1942 History and Milestones of Pfizer South AfricaLeadership Team The most amazing part of my job is being part of a team that finds a solution to a problem without an obvious answer.

6 It s to innovate, to be part of improving healthcare for individuals, and this team here at Pfizer does that every singleday. Jennifer PowerCOUNTRY MANAGERJ ennifer PowerCOUNTRY MANAGERD oreen NelHUMAN RESOURCES DIRECTORM atthew MoodleyLEGAL DIRECTORW illiam ThemaneBUSINESS ANALYTICS & INSIGHTS LEADL arne PearsonPRODUCT QUALITY LEADM ahnqwa KhumaloFINANCE DIRECTORDr. Tobeka BoltinaMEDICAL DIRECTORR hulani NhlanikiPFIZER INNOVATIVE HEALTH CLUSTER LEADB ridget BarnardLOGISTICS & SUPPLY CHAIN MANAGERPaul BrandSALES DIRECTORM arianne ZennonCOUNTRY REGULATORY HEADE laine CrossBUSINESS OPERATIONS LEADCarl SmithBUSINESS TECHNOLOGY LEADK aren HulettMARKETING DIRECTORA tetia VisagieGLOBAL COMMERCIAL OPERATIONS CLUSTER LEADJ ohnny MolotoDIRECTOR PUBLIC AFFAIRS POLICY ACCESS & COMMUNICATIONSSue CartwrightPFIZER CONSUMER HEALTH COMMERCIAL LEAD7 Enters SA market with distribution via Petersen into agricultural sectorAcquires Choats Co.

7 And African Chemical CorporationSets up own pharmaceutical promotional activity in SAWorld headquarters established inNew YorkJohannesburg becomes regional HQ for Southern Africa19511950s1962195319611967 Researchand Development Research and Development is at the heart of fulfilling our purpose to help people live healthier lives. Innovation is also the key to sustaining our growth and profitability. As such, the quest for innovative solutions invigorates the Pfizer community globally, and we have more than 200 new R&D collaborations active are advancing next-generation science to accelerate the development of breakthrough medicines and vaccines, and translate technologies into therapies that significantly improve patients process is arduous and expensive: it takes an average of 12 years for a drug to reach the market.

8 We therefore focus our resources in disease areas with the best chance of scientific and commercial success. Clinical studies find the answers necessary to develop innovative new therapies, and clinical trials make it possible for participating patients to receive state-of-the-art care from the leading experts in the field. In South Africa alone, we run over 20 Clinical Trials at 75 Trial Centres annually. We re contributing to the knowledge economy, we re contributing to innovation, and we are contributing to the man in the street in making sure that the right vaccine gets to where it needs to get to so that he can focus on other aspects of life. Scientific CollaborationsBiovac Technology Transfer The Pfizer -Biovac Technology Transfer is a public-private initiative to locally manufacture a vaccine crucial for the prevention of pneumonia-related deaths, particularly in children up to the age of five.

9 Launched in 2015, the project entails a skills and technology transfer from Pfizer to Biovac that will provide it with the capability to manufacture the vaccine by 2019. Morena MakhoanaBIOVAC CEOP ietermaritzburg manufacturing plant commissionedFurther acquisitions and mergers grow the companyCelebrates 150th anniversaryForbes Company of the YearAchieves Top 10 status in the industry19681970s1999 Our supplier quality management systems help ensure high quality materials are procured for our conveyance security standards enable our medicines to be transported safely and help prevent illicit dugs from entering the corporate supply enact applicable local market legislation and regulations that strengthen our supply security programmes help protect our warehousing facilities and warehouses from global packaging technology programme is designed to help prevent counterfeiting of our global bar coding programme allows us to

10 Add authentication capability to our established monitoring systems help us scrutinise the marketplace for the presence of counterfeit and unsafe Chain Security History and Milestones of Pfizer South Africa9 Merges with Warner-LambertTop 5 pharma company in SAMoU with DoH: establishes anti-fungal partnership programme to help treatment of HIV/AIDSA cquires Pharmacia CorporationPartners with Biovac Institute in a Technology Transfer InitiativeAcquires Wyeth2000200220152009An environment in which everyone in Pfizer understands and embraces their responsibility for protecting product quality and patient safety. Quality Culture is and has always been the key to enable us to provide safe and quality holistic, multi-faceted approach to ensure product quality and adherence to Good Manufacturing Practice (cGMP).