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PHARMACOLOGICAL PRINCIPLES - American Nurses …

Z Drugs with a low therapeutic index (e.g., lithium, 0.5–1.2 mEQ/L) have a low margin of safety; that is, the therapeutic dose and the toxic dose are close together. X Tolerance: The process of becoming less responsive to a particular drug over time X Tachyphylaxis: An acute decrease in the therapeutic response PMHNP PHARMACOLOGICAL ...

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