Premia 2.5 Continuous & Premia 5 Continuous - …

1 Premia Continuous & Premia 5 Continuous Conjugated Oestrogens and Medroxyprogesterone acetate Tablets Consumer Medicine Information What is in this leaflet thinning of the bones (osteoporosis), taking oestrogen on its own as HRT. which can cause fractures, in some may lead to irregular bleeding and a This leaflet answers some of the women. Premia Continuous is used disorder of the uterine lining common questions about Premia by women who still have a uterus (endometrium) called endometrial Continuous Tablets. It does not (womb). hyperplasia, which can lead to contain all of the available If your doctor thinks you will need to endometrial cancer. Progestogens information. take HRT for a long time, including such as MPA help protect the uterine for the prevention of osteoporosis, lining from developing this disorder.

2 It does not take the place of talking to your doctor or pharmacist. your doctor will have considered the Ask your doctor if you have any benefits and risks of other treatments questions why Premia Continuous All medicines have risks and before prescribing Premia has been prescribed for you. benefits. Your doctor has weighed Continuous for you. Your doctor may have prescribed it the risks of you taking Premia Continuous against the benefits they for another use. How it works expect it will have for you. This medicine is available only with Menopause occurs naturally in a doctor's prescription. If you have any concerns about this women usually between the ages of medicine, ask your doctor or Premia Continuous is not addictive. 45 and 55. During menopause, your pharmacist. Premia Continuous is not suitable for body produces less oestrogen than it Your doctor and pharmacist have did beforehand.

3 This can cause birth control, and it will not restore more information. symptoms such as "hot flushes", a fertility. Keep this leaflet with the medicine. sudden, intense feeling of heat and This medicine is not expected to You may need to read it again. sweating throughout the body. Some affect your ability to drive a car or women also have problems with operate machinery. dryness of the vagina causing discomfort during or after sexual What Premia intercourse. Some women develop Continuous is used osteoporosis during or after Before you take for menopause. This is a thinning of the Premia Continuous bones that makes them weaker and Premia Continuous is a type of more likely to break, especially the When you must not take treatment called hormone bones of the spine, hip and wrist. Premia Continuous replacement therapy (HRT) and When given during or after contains the hormones conjugated menopause, oestrogens can help HRT should only be used if you oestrogens and medroxyprogesterone control the symptoms.

4 Have been fully informed of the acetate (MPA). risks. Conjugated oestrogens and Premia Continuous helps to relieve medroxyprogesterone acetate are The decision to use HRT should be the discomfort many women feel similar to the hormones produced by based on your particular needs and during and after menopause, the ovaries before menopause. health, and made after a careful including symptoms such as "hot medical evaluation. Women who still have a uterus must flushes", sweating and vaginal take both oestrogen and progestogen dryness. It also helps to prevent as part of HRT. This is because Premia Continuous 1. Do not take Premia Continuous to endometrial or cervical cancer Tell your doctor if you are allergic prevent heart attacks, stroke or abnormal genital bleeding, which to any foods, dyes preservatives or dementia.

5 Your doctor has not investigated any other medicines. A study called the Women's Health a problem with blood clots Tell your doctor if you have: Initiative indicated increased risk of forming in your blood vessels, a family history of breast cancer heart attack, stroke, breast cancer, such as painful inflammation of nodules, lumps or cysts in your and blood clots in the legs or lungs in the veins (thrombophlebitis) or breasts or any other benign breast women receiving treatment with a the blockage of a blood vessel in product containing conjugated condition (not cancer). the legs (deep vein thrombosis or oestrogens mg and (MPA). fibroids or other benign tumours DVT), or lungs (pulmonary The Women's Health Initiative embolism) of the uterus (not cancer). Memory Study indicated an unusual or irregular genital heart disease or stroke increased risk of dementia in women bleeding or spotting aged 65years and over taking very high blood pressure that is Endometriosis (material similar to not properly controlled the lining of the uterus growing conjugated oestrogens and MPA.)

6 It is assumed that these risks will be problems with your breasts that outside the uterus, causing pain or similar for other medicines your doctor has not investigated bleeding containing oestrogen and liver disease. high blood pressure progestogen combinations. blood clotting problems. liver problems Talk regularly with your doctor If you are not certain whether a condition called porphyria about whether you still need these may apply to you, or you are hearing difficulties treatment with Premia worried about anything in this list, Continuous . yellowing of the whites of the talk to your doctor. Treatment with oestrogens, with or eyes or skin (jaundice) during Do not take this medicine if you pregnancy or when taking without progestogens, should be used are pregnant or think you are oestrogens ( birth control pill at the lowest effective dose and for pregnant.)

7 Or HRT). the shortest period of time. Pregnancy must be excluded before fluid retention Do not take Premia Continuous if you take Premia Continuous . you have an allergy to: kidney problems Do not take Premia Continuous if any medicine containing heart problems you are breast feeding. conjugated oestrogens or MPA, diabetes the active ingredients in Premia Oestrogens have been found in breast Continuous milk and may reduce the production migraine of breast milk. asthma any of the ingredients listed at the end of this leaflet Do not give this medicine to a epilepsy child. any other similar medicines Lupus (systemic lupus containing oestrogen or Do not take this medicine after the erythematosus). progestogen, such as other HRT expiry date (EXP) printed on the Hereditary angioedema (swelling medicines or oral contraceptives pack or if the packaging is torn or of the face, lips, tongue or throat ("birth control pill").

8 Shows signs of tampering. that may cause difficulty Some of the symptoms of an allergic If it is expired or damaged, return it swallowing or breathing). reaction may include: to your pharmacist for disposal. gall bladder disease shortness of breath If you are not sure whether you high levels of blood fats should start taking this medicine, wheezing or difficulty breathing talk to your doctor. high or low levels of calcium in swelling of the face, lips, tongue the blood or other parts of the body Before you start to take underactive thyroid gland. rash, itching or hives on the skin. Premia Continuous obesity. Do not take Premia Continuous if You must have a thorough medical Tell your doctor if anyone in your you have or have had any of the check-up before starting Premia immediate family has had blood following medical conditions: Continuous for the first time or if clots in the deep veins of the legs or breast cancer you are taking it again after a break.

9 Premia Continuous 2. blood vessels of the lungs, a stroke aminoglutethemide used to treat How much to take or heart attack. breast cancer and a disease called Treatment consists of a 28-day cycle. Cushings syndrome. Taking Other Medicines Grapefruit juice may also affect how Take one tablet daily. Tell your doctor if you are taking well Premia Continuous works. Take all tablets in a blister pack birth control pills. before starting a new pack. Premia Continuous is not a If you have not told your doctor How long to take it contraceptive. Since pregnancy may about any of the above, tell them be possible early in menopause, before you start taking Premia Continue to take your medicine for while you are still having menstrual Continuous as long as your doctor tells you. periods, you should ask your doctor Your doctor can discuss the risks and Your doctor and pharmacist have about another (non-hormonal) benefits of long-term treatment with more information on medicines to be method of birth control.

10 HRT in your particular case. careful with or avoid while you are Tell your doctor or pharmacist if taking this medicine. you are taking any other If you forget to take it medicines, including: If less than 12 hours has passed all prescription medicines from the time you normally take all medicines, vitamins, herbal How to take Premia Premia Continuous , take the supplements or natural therapies Continuous missed tablet. you buy without a prescription Take the next tablet at the usual time. from a pharmacy, supermarket, Follow all directions given to you by your doctor or pharmacist If more than 12 hours has passed, naturopath or health food shop. discard the missed tablet and take carefully. Some medicines may be affected by the next tablet when you normally Premia Continuous or may affect They may differ from the would.