PRODUCT REFERENCE GUIDE ADVANCED WOUND …

1 PRODUCT REFERENCE GUIDEADVANCED WOUND CARESYSTAGENIX This GUIDE has been developed to provide a useful overview of the products available from Let s HeaL This section describes our passion and agility to drive innovation that has just one goal: to help heal wounds, fast. This is captured by our callto action: Let s HeaL , which represents our unique integrated WOUND healing portfolio, built of four categories: SECTION PRODUCT Information GuidelinesThis section includes information on the Systagenix ADVANCED WOUND care portfolio. It contains details on the technical aspects of the dressings, how the dressings work and the clinical benefits you can expect when using the dressings. You will also find the indications and the specific WOUND types that the dressings are suitable for. All in one simple, easy place for REFERENCE . SECTION sizes Codes and Ordering InformationThis section contains everything needed to order your Systagenix products, including individual sizes and codes 4 Let s HeaL SECTION 6 Introduction to Diagnostics WOUNDCHEK PrOTeASe STATUS 8 SILVERCEL NON-ADhereNT Dressing 10 ACTISORB Activated Charcoal Dressing with Silver12 INADINE Povidone Iodine Non-Adherent Dressing14 SILVERCEL hydro-Alginate with silver 16 PROMOGRAN Matrix OrC/Collagen Dressing18 PrOMOGrAN PRISMA OrC/Collagen with Silver/OrC Dressing20 FIBRACOL PLUS Collagen/Alginate Dressing 22 TIELLE Family.

2 Hydropolymer Adhesive Dressings 26 ADAPTIC TOUCh Non-Adhering Silicone Dressing28 ADAPTIC Non-Adhering Dressing30 ADAPTIC DIGIT Non-Adhering Digit Dressing32 BIOCLUSIVE Transparent Dressing 34 NU-DERM Alginate Dressing 36 NU-DERM hydrocolloid Dressing 38 NU-GEL hydrogel with Alginate 40 NU-GEL WOUND Dressing 42 DYNA-FLEX Multi-Layer Compression System44 ALGOSTERIL Calcium Alginate Dressing46 TRIONIC Alginate Dressing with calcium, zinc & manganese ions48 N-A and N-A Ultra Dressing SECTION 50 sizes Codes and Ordering Information 2 IntroductionContents 34 Section Let s Heal Section 5 WOUNDCHEK PrOTeASe STATUSSILVERCEL NON-ADhereNT with easyLIFt SILVERCEL ACTISORB INADINE PROMOGRAN PrOMOGrAN PRISMA FIBRACOL PLUSTIELLE Family with LiquaLock ADAPTIC FamilyBIOCLUSIVE NU-DERM AlginateNU-DERM hydrocolloidNU-GEL hydrogelNU-GEL WOUND DressingALGOSTERIL TRIONIC N-A and N-A UltraDYNA-FLEX To finally provide WOUND care tools which aid a correct and timely diagnosis, just like other areas of medicine nowadays.

3 To protect from infection, whilst also managing the secondary symptoms of exudate, Pain, and promote WOUND healing in ways that standard dressings may not be able provide a comfortable and effective healing environment for all types of NON-ADHERENTTIELLE ADAPTIC TOUCH PROMOGRAN PROMOGRANPRISMA Let s Protect Let s Test Let s Promote Let s Comfort WELCOME TO 21ST CENTURY WOUND CARE The development of specific diagnostic tests for use in wounds has the potential to revolutionise their treatment, and help improve standards of WOUND care (while) aiding in the cost effective use of limited resources. World Union of WOUND Healing Societies. Principles of best practice: A consensus document: MEP Ltd. London, suggests that wounds that heal well have a lower overallProtease activity than those that heal poorly. As a result, a test that readily provides this information might be clinically useful in understanding how well a WOUND is healing, and whether an intervention that modulates Protease activity may be 76 Section PRODUCT InformationIMAGINE A WORLD WITHOUT YOU WON T BE ABLE TO IMAGINE A WORLD WITHOUTSILVERCEL NON-ADHERENT DRESSINGWHAT IS IT?

4 SILVeRCeL NON-ADhereNT Dressing is the next generation of Silver Antimicrobial Dressing with the unique feature of a Non-Adherent layer to maximise protection of the WOUND bed, particularly at dressing unique composition: a mixture of alginate, carboxymethylcellulose (CMC), and silver coated nylon fibres manages exudate effectively in infected or heavily colonised wounds. The unique easyLIFt film layer keeps the dressing simple and convenient to use, minimising pain and trauma at dressing change for your DOES IT WORK? sILVeRCeL NON-ADhereNT is designed to absorb and retain high amounts of exudate, whilst allowing easy, intact and atraumatic pain free removal from the WOUND silver ions within the dressing protect the WOUND from bacterial NON-aDHeReNt designed not to stick Maintains a sustained release of silver ions for up to 7 days in vitro 1 Stays strong for intact removal, even when wet 2 Optimally spaced perforations allow free flow of exudate into the dressing, and also ensure the dressing stays intact Conforms to the WOUND bed for complete coverage when moist, and is designed not to stick to the WOUND bed at dressing change sILVeRCeL NON-ADhereNT has been proven to be 75% Less Adherent than the market leading silver dressing 3 INDICATIONS: Suitable for use under medical supervision, in the management of infected wounds, or wounds which have an increased risk of infection.

5 May help reduce infection in moderate to heavily exuding partial and full-thickness wounds including: Pressure ulcers Venous ulcers Diabetic ulcers Donor sites Traumatic and surgical woundsPlease refer to package insert for full 9 References: 1. Clark, r PhD; Stephens, S-A (BSc (hons); Del Bono, M; Abloye, O; Bayliff, S BSc (hons); The evaluation of Absorbent Silver containing Dressings In Vitro; Systagenix WOUND Management. Poster Presentation CAWC Quebec City October 20092. , Michelle Del Bono, Sally-Anne Stephens, Omotayo Abioye, Simon Bayliff: Simulated in use tests to evaluate a Non-Adherent Antimicrobial silver alginate dressing. Presentation Quebec City October Clark,Stephens,Del Bono: From Lab to Leg The importance of correlating in-vitro and in-vivo test systems to clinical experience. Poster presented SAWC PeR CaRtONCaRtONs PeR BOxBOxes PeR CaseCAD70505cm x 5cm105 (50 eaches)10 (500 eaches)CAD701111cm x 11cm105 (50 eaches)12 (600 eaches)CAD702010cm x 20cm55 (25 eaches)8 (200 eaches) x (25 eaches)6 (150 eaches)8 Section PRODUCT InformationSILVERCEL NON-ADHERENT ACTISORB ACTIVATED CHARCOAL DRESSING WITH SILVER WHAT IS IT?)

6 ACtIsORB Dressing consists of activated charcoal impregnated with silver and encased in a nylon sleeve. aCtIsORB Dressing is designed to trap WOUND malodour whilst protecting the WOUND from infection. By removing harmful elements from the WOUND , a more stable WOUND healing environment can be achieved. HOW DOES IT WORK? Activated charcoal traps odour and bacterial toxins Binds toxins which are known to impair healing 5,6 reduces WOUND odour and improves patient s quality of life 2 Silver Kills bacteria1 reduces infection and exudates 3, 4 Effective wet or dry Consistent adsorption of bacteriaINDICATIONS: aCtIsORB Dressing may help to reduce infection in partial and full thickness wounds including: Pressure Ulcers Surgical wounds Diabetic Ulcers First and second degree burns Venous UlcersPlease refer to package insert for full 11 References: 1. russel AD et al. Antimicrobial activity and action of silver. Progress in Medicinal Chemistry. 31, 351-370, elsevier Service 19942.

7 Price Pe et al. J WOUND Care; 9(2):93-953. Milward PA. Nursing Times 1991; 87(13) Leak, K. PeG site infections: a novel use for ACTISOrB* Silver J Community Nurs. 2002; 7 (6)5. Kramer A et al Antibacterial activity and endotoxin-binding capacity of ACTISOrB* Silver 220. J hospital Infect. 2003; 53: robson MC et al. WOUND healing alterations caused by infection. Clinics in Plastic Surgery 1990; 17: PeR CaRtONCaRtONs PeR BOxBOxes PeR x (50 eaches)28 (1400 eaches) x (50 eaches)9 (450 eaches)MAS19019cm x (50 eaches)12 (600 eaches)10 Section PRODUCT InformationACTISORB INADINE PVP-I NON-ADHERENT DRESSING WHAT IS IT?INaDINe PVP-I Non-Adherent Dressing consists of a low adherent knitted viscose fabric impregnated with a polyethylene glycol (PeG) base containing 10% Povidone Iodine; equivalent to available Dressings are designed to protect the WOUND , even if infected. HOW DOES IT WORK? The Povidone molecule provides an effective release of iodine. The polyethyleneglycol provides a water-soluble environment, which allows the Iodine to reach the bacteria in the WOUND .

8 INaDINe Dressing has long been established for use in WOUND care, its features include: Povidone Iodine controls bacteria by reducing bacterial load and inhibits infection 1-3 Povidone Iodine is a broad spectrum antimicrobial 1-3 Safe for use on adults and children and in combination with systemic antibiotics 1-3 INDICATIONS: INaDINe Dressing is designed to protect the WOUND , even if infected. INaDINe Dressing is indicated for the management of ulcerative wounds and may also be used for the prevention of infection in minor burns and traumatic skin loss refer to package insert for full 13 References: 1. Mclure et al Journal of hospital Infection. 1992 Aug;21(4):291-9. 2. Goldenheim Postgrad. ,1993;69 ( ) Adams l. WOUND healing altered with the use of povidone iodine. PeR CaRtONCaRtONs PeR BOxBOxes PeR CaseP014815cm x 5cm2510 (250 eaches)4 (1000 eaches) x (250 eaches)2 (500 eaches) x (100 eaches)4 (400 eaches)12 Section PRODUCT InformationINADINE SILVERCEL ANTIMICROBIAL DRESSING WHAT IS IT?

9 SILVeRCeL is a sterile, non-woven pad composed of a high G (guluronic acid) alginate, carboxymethylcellulose (CMC) and silver coated nylon fibres. The unique composition of sILVeRCeL is designed to manage exudate and help control infected or heavily colonised wounds. HOW DOES IT WORK? sILVeRCeL has a number of features that can help with controlling Infection: sILVeRCeL minimises the risk of maceration and leakage1, 2 and has been proven to absorb and retain fluid even under compression In vitro studies show that the level of silver released from sILVeRCeL is maintained beyond 7 days 3 Designed not to break up in the WOUND 1,4 sILVeRCeL maintains its strength within a moist WOUND environment1,4 INDICATIONS: sILVeRCeL is intended for use in the management of all moderate to heavily exuding partial and full thickness chronic wounds including: pressure ulcers, venous ulcers, diabetic ulcers, donor sites, traumatic and surgical wounds. As the PRODUCT contains alginate it may assist in supporting the control of minor bleeding in superficial wounds.

10 It is also suitable for use under medical supervision, in the management of infected wounds, or wounds in which there is an increased risk of refer to package insert for full 15 References: 1. Teot L et al. The management of wounds using SILVerCeL hydro-Alginate. Wounds UK Supplement. (2)2. Addison D et al. An Antimicrobial Dressing for moderate to heavily exuding infected and critically colonised wounds. Systagenix WOUND Management Gargrave Poster presented at eWMA Pisa May 20033. rennison T et al. evaluations of a silver hydro-Alginate dressing to Determine suitability for use on chronic wounds. Systagenix WOUND Management Gargrave Poster presented at eWMA Prague May Clark r, PhD; Stephens S-A, BSc (hons); Del Bono, M; Abioye, O; Bayliff S, BSc (hons). Simulated in-use tests to evaluate a non-adherent antimicrobial silver alginate WOUND dressing. SAWC, Texas, Dallas 2009 CODesIZeeaCHes PeR CaRtONCaRtONs PeR BOxBOxes PeR CaseCAD0505cm x 5cm105 (50 eaches)12 (600 eaches)CAD01111cm x 11cm105 (50 eaches)12 (600 eaches)CAD02010cm x 20cm55 (25 eaches)8 (200 eaches) x (25 eaches)6 (150 eaches)14 Section PRODUCT InformationSILVERCEL PROMOGRAN PROTEASE MODULATING MATRIX WHAT IS IT?