SAFETY DATA SHEET - zoetisUS.com

1 SAFETY data SHEET1. IdentificationIsofluraneProduct identifierOther means of identificationIsoFlo * 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether;2-Chloro-2-(difluoromethoxy)-1,1,1 -trifluoroethane * Forane * Forene * Isoflurane liquidSynonymsVeterinary product used as anesthetic agentRecommended useNone restrictionsManufacturer/Importer/Suppli er/Distributor informationManufacturerCompany Name (US)Zoetis Sylvan WayParsippany, New Jersey 07054 (USA)Rocky Mountain Poisonand Drug Center1-866-531-8896 product Support/TechnicalServices1-800-366-5288 Emergency telephonenumbersCHEMTREC (24 hours): 1-800-424-9300 International CHEMTREC (24 hours): +1-703-527-3887 Contact Name (EU)Zoetis Belgium 201930 ZaventemBelgiumEmergency telephonenumberInternational CHEMTREC (24 hours).

2 +1-703-527-3887 Contact Hazard(s) identificationNot hazardsCategory 2 Skin corrosion/irritationHealth hazardsCategory 2 ASerious eye damage/eye irritationCategory 2 Reproductive toxicity (the unborn child)Category 3 narcotic effectsSpecific target organ toxicity, single exposureNot hazardsNot defined hazardsLabel elementsSignal wordWarningHazard statementCauses skin irritation. Causes serious eye irritation. May cause drowsiness or of damaging the unborn statementPreventionObtain special instructions before use. Do not handle until all SAFETY precautions have been readand understood. Avoid breathing mist or vapor. Wash thoroughly after handling. Use onlyoutdoors or in a well-ventilated area.

3 Wear protective gloves/protective clothing/eyeprotection/face / 8 Material name: Isoflurane3055 Version #: 03 Revision date: 11-12-2016 Issue date: 07-06-2015 SDS USResponseIf exposed or concerned: Get medical advice/attention. If inhaled: Remove person to fresh air andkeep comfortable for breathing. Call a poison center/doctor if you feel unwell. If in eyes: Rinsecautiously with water for several minutes. Remove contact lenses, if present and easy to rinsing. If eye irritation persists: Get medical advice/attention. If on skin: Wash withplenty of water. If skin irritation occurs: Get medical advice/attention. Take off contaminatedclothing and wash before in a well-ventilated place.

4 Keep container tightly closed. Store locked of contents/container in accordance with local/regional/national/international (s) not otherwiseclassified (HNOC)None informationAnesthetic drug: may cause central nervous system and cardiovascular system Composition/information on ingredientsSubstancesCAS number%Common name and synonymsChemical nameIsoFlo 1- chloro- 2, 2, 2- trifluoroethyl difluoromethylether; 2- Chloro- 2- (difluoromethoxy) - 1, 1, 1- trifluoroethaneForaneForeneIsoflurane liquid26675-46-7100 Isoflurane4. First-aid measuresRemove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISONCENTER or doctor/physician if you feel contaminated clothing.

5 Wash with plenty of soap and water. If skin irritation occurs: Getmedical advice/attention. Wash contaminated clothing before contactImmediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact rinsing. Get medical attention if irritation develops and contactRinse mouth. Get medical advice/attention if you feel unwell. If ingestion of a large amount doesoccur, call a poison control center immediately. Never give anything by mouth to a victim who isunconscious or is having cause drowsiness and dizziness. Headache. Nausea, vomiting. Severe eye may include stinging, tearing, redness, swelling, and blurred vision. Skin irritation. Maycause redness and importantsymptoms/effects, acute anddelayedAnesthetic drug: may cause central nervous system and cardiovascular system effects.

6 Monitorrespiratory, cardiac and central nervous system. Provide general supportive measures and treatsymptomatically. Keep victim under observation. Symptoms may be of immediatemedical attention and specialtreatment neededIF exposed or concerned: Get medical advice/attention. Ensure that medical personnel are awareof the material(s) involved, and take precautions to protect themselves. Show this SAFETY datasheet to the doctor in information5. Fire-fighting measuresWater fog. Foam. Dry chemical powder. Carbon dioxide (CO2).Suitable extinguishing mediaDo not use water jet as an extinguisher, as this will spread the extinguishingmediaDuring fire, gases hazardous to health may be formed.

7 Fine particles (such as dust and mists) mayfuel hazards arising fromthe chemicalSelf-contained breathing apparatus and full protective clothing must be worn in case of protective equipmentand precautions for firefightersMove containers from fire area if you can do so without fightingequipment/instructionsUse standard firefighting procedures and consider the hazards of other involved methodsFire may produce toxic or corrosive gases. Vapors may ignite. Fine particles (such as mists) mayfuel fire hazards2 / 8 Material name: Isoflurane3055 Version #: 03 Revision date: 11-12-2016 Issue date: 07-06-2015 SDS US6. Accidental release measuresWear appropriate protective equipment and clothing during clean-up.

8 Keep unnecessary personnelaway. Keep people away from and upwind of spill/leak. Ensure adequate ventilation. Ventilate thecontaminated area. Eliminate all ignition sources (no smoking, flares, sparks, or flames inimmediate area). Avoid breathing mist or vapor. Avoid contact with eyes, skin, and clothing. Do nottouch damaged containers or spilled material unless wearing appropriate protective clothing. Localauthorities should be advised if significant spillages cannot be contained. For personal protection,see section 8 of the precautions,protective equipment andemergency proceduresEnsure adequate ventilation. ELIMINATE all ignition sources (no smoking, flares, sparks or flamesin immediate area).

9 Prevent product from entering Spills: Stop the flow of material, if this is without risk. Dike the spilled material, where this ispossible. Cover with plastic SHEET to prevent spreading. Use a non-combustible material likevermiculite, sand or earth to soak up the product and place into a container for later product recovery, flush area with Spills: Wipe up with absorbent material ( cloth, fleece). Clean surface thoroughly toremove residual return spills to original containers for re-use. For waste disposal, see section 13 of the and materials forcontainment and cleaning upAvoid discharge into drains, water courses or onto the precautions7. Handling and storageDo not handle, store or open near an open flame, sources of heat or sources of ignition.

10 Protectmaterial from direct sunlight. Use only with adequate ventilation. Wear personal protectiveequipment. Avoid breathing mist or vapor. Avoid contact with eyes, skin, and clothing. Avoidprolonged exposure. When using, do not eat, drink or smoke. Wash hands thoroughly afterhandling. Observe good industrial hygiene practices. Use care in handling/storage. Should behandled in closed systems, if possible. Avoid release to the for safe handlingStore locked up. Store in tightly closed original container in a dry, cool and well-ventilated below 30 C (86 F). Store away from incompatible materials (see Section 10 of the SDS).Keep away from heat and sources of ignition. Keep out of the reach of for safe storage,including any incompatibilities8.