Sponge Metal TM Catalysts - jmprotech.com

1 Sponge MetalTMCatalystsSolutions for the Synthesis of Pharmaceuticals, Bulk and Fine ChemicalsAboutJohnsonMattheyJohnsonMatth eyis a recognizedworldleaderin preciousand over30 countries,our extensivenetworkofresourcesenablesus to providea full rangeof servicesand developmentand manufactureof catalystsandchemicals,analyticaland characterizationtechniques,and the recoveryand refiningof PlatinumGroupMetals(PGM) continuedto developits technologyfor nearly200 years,demonstratingthe company'sabilityto maintainworldleadershipby adaptingconstantlyto its own environmentalpolicies,manyof JohnsonMatthey'sproductshavea majorbeneficialimpacton the environmentand enhancethe qualityof life for millionsaroundthe HeadquartersRo yst on, UKJo hn so n Matthey s Sp on ge Meta l Ca talysts manufa ct urin g site isloc at ed in Se vie rville, Ten nesse e, USA,at the foot hills of the beautifulGr ea t Smo ky Mo un tain s.

2 The pro duction pla nts and la bor ato ries aremo der n fa cilit ies ca pab le of pro ducinghighqua lity allo y powders andact iva ted cata lys ts wit h gr eat cons is ten cy. Th e pla nt be cam eISO-900 2 cer tifie d in 1993 and ISO 900 1-20 00 ce rtif ie d in 200 ong e Met al Cat alystsare prepa red fro m alloysof tr ansitionme ta ls an d alu mi num . Th e al um inu m is lea ch ed fr om the alloyst ru ct ure, le aving beh in d an act ive Metal surf ace co vere d or sa turatedwit h ads orb ed hy dr ogen . The acti va ted cata lys ts ar e sto red und erwat er to prot ect themfro m ox ida ti on. Spo nge Meta l Ca ta lys tsar e in a fully act ive form wh en sh ip ped and req uire no prea ctivationpr ior to use .Jo hns on Mat th ey op era tes its ma nu fa ct ur in g facilities withmaximumeff ort an d commitmentto pro du ce a sa fe pr oduc t in a sa fe wo rking atmospherewithminimumdetr imental ef fe cton the env iro ge Meta lTMCata ly sts Manu fac tur in gSe vier vil le , Ten ne ss ee USAALLOYPOWDERREACTIONALLOYPOWDERALLOYPO WDERREACTIONAINiSODIUMALUMINATEALLOYPOWD ERSODIUMHYDROXIDESPONGEMETALCATALYSTSPON GEMETA LCATALYSTTMS pongeMetalTMCata lys ts Man ufactu ri ng Pr ocessMe tal s1 Mur ray Ran ey, US Pa ten t 1,6 28,1 90 (1 927 )

3 Cool ingCrushingScre eni ng2N i2Al3+ 6N aOH + 6H2O4Ni0+ 6N aAlO2+ 9H2+In 19 27, a pa te nt1was awar de d to Mu rra y Ra ne y of Tenn esseefor a newcla ss of me tal ca talystspr odu ced fr om th e all oys of va rio us base e MetalTMCata lys ts Ap pli ca tion sHydrogenation of Nit ro Gr oupsto AminesOtherApplicationsTy picalCataly st s2-N itro -2 -me th yl-1 -p ropanolto2-Amino-2 -me th yl-1 -p ropanolA- 5000 , A-7000 Reaction Conditions1 Temperature100 -2 00 CPres sure10- 20 0 at mTypi cal Catalyst sA- 5000,A-6 EB9 , A- 40 00 Dinit rotol ueneToluenediami ne (TDA)H2Bu lk Che mica lsHy drogenation of Carbonyl GroupsOtherApplicationsTy picalCatalyst sBu ty ra ld ehyd e to Bu tanolA-5 000, A-7000,A-7069Be nza ld ehyde to Be nzyl Alc oh ol A-5 000, A-7000,A-70692-E th ylh exa nal to 2-E thy lh ex an ol A-5 000, A-3B00,A-7069 ReactionConditions2 Temperature50-1 75 CPres sure13-1 50 atmTy picalCat aly st sA-7063,A-7 B6 3, A-7 069, A-7 B693-H ydroxypropanal1,3 -Pro panediolH2 Hydrogenation of Nit riles to AminesOther ApplicationsTy picalCataly stsDia min obu ta neA- 4000 Reaction ConditionsTemperature60- 10 0 CPres sure20- 50 atmTypi cal Catalyst sA- 4000,A- 400A, A- 4F 00 Adiponitril eHexamethy lenediamine(HMDA)H2 Deh ydrogenat ion of AlcoholsReactionConditions3 Temperature170-2 30 CTypicalCatalystsA-4 000, A-7 000Is opropyl AlcoholAcetoneH2CH3NO2NO2CH2 OHCH2CH=== O CH2 OHCH2CH2 OH C N(CH2)4C N CH2 NH2(CH2)

4 4CH2 NH2 OH CH3 CH CH3O CH3 C CH3CH3NH2NH21US Pa te nt #3 ,935 ,264(19 74 ), US Pa te nt #3 ,517,063(1970),US Patent#4,2 24,2 49 (1 980 ) 2US Pa tent #5, 463,144(1995) 3US Patent#4,380,673(1983)Hydrogenation of PolyolsOther ApplicationsTypicalCatalystsMa nnito lA-7 063, A- 7B63,A-7B73, A-7069,A-7B69Ma ltit olA-7 063, A- 7B63,A-7B73, A-7069,A-7B69Xy lito lA-7 063, A- 7B63,A-7B73, A-7069,A-7B69La ctito lA-7 063, A- 7B63,A-7B73, A-7069,A-7B69 Reaction ConditionsTemperature10 0-15 0 CPr essure20-20 0 atmTypical CatalystsA- 7063,A-7 B63 , A-7 069,A-7B69n=4, Dext ros en=4 , Sor bitolH2Sp ec ia lt y Chem ic al sHydrogenat ion of Fatty Nit ri les to FattyAminesUS ING AMCA T CAT ALYST SReactionConditionsTemperature40-2 00 CPres sure10-3 0 atmTyp ica l Cat al ystsAMCAT- 5,AMCAT-7, A-7 B6 3, A- 8B46 Stearyl NitrileStearyl AmineH2 ReductiveAlkyl ationReactio n ConditionsTem perature15 0- 18 0 CPres sure1-3 atmTypi cal Cata ly st sAM CA T- 5, A- 7B63 AMCAT-5 343 , A- 50 00.

5 A-7000 Ali phaticPrimary AmineTertiaryDimethylAliphaticAm ineH2Hy drogenation of Olefins to Alka nesOtherApplicationsTypicalCatalystsCro to nald eh yde to Butyr alde hy de A-5 000Su lfo le ne to Su lfo la neA-5 000 ReactionConditionsTemperature25-2 00 CPres sure1-2 00 atmTypicalCatalystsA-5000H2 Forma ld eh ydeCHO(CHOH)nCH2OH CH2OH(CHOH)nCH2OH C N(CH2)16CH3 NH2CH2(CH2)16CH3 CH2 NH2(CH2)nCH3 N(CH2)n+1CH3 CH3CH3R CH=== CH RR CH2 CH2 RSpongeMetalTMCata lys ts App lica ti on sReductiveAl kyla tion (Ster eoselective)4 Reaction ConditionsTem peratureRTPr essure3 atmTypi cal Catalys tsA-5000H2Ph ar ma ce utic al sHydrogenation of Nitri les to Amine s5 ReactionConditionsTemperatureRTPres sure12 atmTypicalCatalystsA-7 000, A-5 000, A-7 063, A-706BH2 Hydrogenation of Azide and Olef in6 Reaction ConditionsTemperatureRTPr essure3 atmTypical CatalystsA- 5000,A-5 E0 9H2Hy drogenation of Nitriles to Ami ne s7 ReactionConditionsTemperatureRTPres sure3 atmTy picalCat aly st sA-7 000, A-5 000, A-70 69H2100%+OCO2 EtH3N+OMeNCO2CO2 EtH2N+OMeNCO2 COOHNCCOOHNH2OR1R20OR1N3R20 OOR1OR2OR2N C H2 NOR2OR2OR1 ONH2OR1R20R20OR1 Spong e MetalTMCata lys ts Ap pli ca tion s4Jo urn al of Org anic Ch emistry (1 988 ), 53 (4 ) 836-44,TetrahedronLetters(199 9), 40 (5), 83 1-8 34 5US Patent#5,132,451(1992) 6 ChemReviews 2003,(103) , 1973 7 TetrahedronLetters(1992), 33( 17)

6 , 2283-84 Pri mar y ActiveTypicalMedianSpongeFamilyCatalysts ComponentPr omotersParticleSize, mCommentsNi ckelA-2000 Nic kelFe30 StandardcatalystsA-5 000 Nic kel 33 Standardcatalystsfor most hydrogenationreactionsA-5 001 Nic kel 33 Standardcatalystsat low pHA-5 009 Nic kel 33 Highclarityand fast filtrationrateA-5 E09 Nic kel 20 High clarityand highactivityA-5 B0 0 Nic kel 50 Standard catalystsfor mosthydrogenationreactionsA-5 F00 Nic kel 85 Fast settle me nt an d fa st filtrationNi ckel/MolybdenumA-7000 Nic kelMo35 HighactivityafterrecyclingA-7 004 Nic kelMo35 HighactivityafterrecyclingA-7 063 Nic kelMo35 StandardcatalystsA-7 B6 3 Nic kelMo50 StandardcatalystsA-7 B7 3 Nic kelMo50 StandardcatalystsA-7 200 Nic kelMo160 Fast SettlementA-7 069 Nic kelMo35 Excellentsettlementand fast filtrationA-7 B6 9 Nic kelMo50 Excellentsettlementand fast filtrationA-7 BC9 Nic kelMo50-65 Excellentsettlementand fast filtrationNi ckel/ChromiumA-4000 Nic

7 KelFe/ Cr35 Standardcatalystsfor nitroand nitrilehydrogenationA-4 F00 Nic kelFe/Cr85 Fast settle men t an d filtr ationNi /P all adiumA-6EB9 Nic kelPd20 Significanthighactivityfor nitrohydrogenationCopperA-3B00 Copper 35 Standardspongecop per catalystsCobal tA-8B46 CobaltFe/ Cr35 High selectivityin someapplicationsAM CAT AMCAT-5 Nic kel 35 Prima ry amin e coate dAMCAT-53 43 Nic kel 35 TertiaryaminecoatedSpongeMetalTMCata lys ts Prod uct Li sti ngPlea se not e th es e are typical va lue s and not oy Pow der s - All pr ec ur so r cat aly sts allo y po wders alon g withcu stomalloy po wders are avai lableuponrequestCus tom er Serv iceJoh nso n Ma tt he y is committed to pro vid in g our customerswiththe best se rvice s. Ou r glo bal sa lesnet wor k of fer s pr omptre sp ons es to cu sto mer need s. Ou r kno wl edg e and expe rti se enableus to pr ovi de our cu sto mer s wi th exce llen t technicalservice: Ca talystsScr een ing Se rvice Proce ss Op timization Proce ss Trou ble Sh oo ting Tailor ed Cat alysts Techn ica l Tr ainingSeminars Ni reco ve ry from sp ent ca talystsAMC AT Sp ecial ty En capsulated CatalystsPr op ri et ar y AM CAT ca ta lystsare activa ted Sp on ge Meta l enca psulated ca talyst s in wh ich waterha s bee n di sp la ce d by an alipha ti c amine.

8 They offeruniq ue handlingand sa fe ty pr ope rtie s, as wellas be in g hi gh ly eff ec tive cat al CAT ca ta lyst s provide plan t ope rat ions wit h th e fo llowingbe nef its : Non- pyrop hor ic Non- dusting Easy to we igh No water ad ded to proce ss No pr eactiva tion Siz e of AMCAT can be adjusted(a typ ica l size: in ch cub es) Va riou s amineco atin gs ava ilab le for directco mpatibilit y wit h cust omer s pr odu ctSponge Me ta l Ca ta lyst s RecoveryJoh nsonMat they off ers ser vi ces for re cla mation of metalvalu e fromspe nt cata lys ts. Aft er use,the spentcatalysts shouldbe handled care fullyin the foll owingpo st-t rea tme nt and stor age method,due to the ir pyr op hor ic pr op erty .Spe nt ca ta lystsre sidu es are classifiedas materialsfor recycling,and the transportof theseresiduesar e sub je ct to cur ren t regu lat ion s.

9 In add iti on to the re gul ati ons gov ern ing was te sh ipm ents ,al l mo vement s of cat alyst s re sid ues must be classifiedand labeledacco rdin g to curr ent inte rna tionaltran spo rt re gul at ions. Ma te rial origi na tin g withinthe EuropeanUnionmu st also be cla ssifiedandla bel ed for sup pl y in acco rd anc e wit h Dir ective1999/45 ensuresafe treat mentof the resi du es and to meetEuropeanHea lt h an d Sa fet y legis lat ion ,JohnsonMat theyrequires a Mat er ial Sa fety Data Sheetfor eachre sid ue retu rn ed. Othe r ma ter ialcont amin atedwi th basemet al s, such as wipes,filtercloths, distillationresidues, etc., shouldbe returnedin a sep ara te mar ked drumfor me ta l re or age Han dl in g & Sa fe tyAc tiv at ed Sponge Me tal Ca ta lyst s ar e pyr opho ric. Cat alystsshouldbe stor ed in sealed con tain ersuntil req ui red fo r use.

10 Dru ms sh oul d be kept in a cool , dry plac e underreasonable condi ti ons (not exposedto the el emen ts of we athe r and ext re mes of temperatu res ide all y kep t be tween 3 to 30oC). Dru ms shouldnot be stor ed nea r oi ls or fla mmabl e liq uids or exposedto combustible va pors due to th e risk of er use, emp ty dru ms can of te n be re tain ed for shipmentof spentcata lystsfo r re taly stsar e shi ppedun der a protect ive laye r of wa ter to preventimmediate oxidation by air. In mostca ses,spe nt ca ta ly st s ar e just as pyr op hor ic as fresh Catalysts ,and shouldbe han dledwit h the sa me the even t of a sp la sh or sp il l, ple ase ref er immediatelyto the Materia l Saf ety Da ta Sh eet (MSDS)fo r det ai led up- to- dat e in fo rma tio n abou t haza rds and safehandlingre co mmendatio ns. If any fu rtherin fo rm at io n is req ui re d, ple ase con ta ct yo ur localsalesrepresentativeor any localsa les of fice lis tedon th e bac k of thi s br och ur tsSpongeMe talTMCat al yst s Standard Pack agi ngCa tal ysts are ship pe d as water-basedslur ries,witha visibleex cessof Sol ids Weight,pounds3502001103512(kg)( )( )(50(15.))