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Supporting Information - codexis.com
SUPPORTING INFORMATION 2 1. Development of a practical through-process for the preparation of Boc amino nitrile 11 Starting from inexpensive, commercially available 4-pentyn-1-ol (S-1), a through-process to Boc amino nitrile 11 via intermediate S-3S1 is depicted in Scheme S-1. Although a Swern oxidation of S-1 could prepare aldehyde S-2 in high yield,S1 scale-up of a Swern oxidation in large ...
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