Tableau Ib. Les isoenzymes CYP avec leurs substrats ...

1 Tableau Ib. Les isoenzymes CYP avec leurs substrats , inhibiteurs et inducteurs Les substrats , les inhibiteurs et les inducteurs avec lesquels on s'attend des interactions cliniques particuli rement importantes sont indiqu s en caract res gras. Pour plus d'informations, voir substrats Inhibiteurs ( concentration plasmatique du substrat) Inducteurs ( concentration plasmatique du substrat) CYP1A2 Clozapine, caf ine, dulox tine, imipramine, m latonine, olanzapine, pirf nidone, rasagiline, ropinirole, ropivaca ne, stiripentol, th ophylline, tizanidine, triamt r ne, zolmitriptan Cim tidine, ciprofloxacine, caf ine, estrog nes et estroprogestatifs, thinylestradiol, fluvoxamine, norfloxacine, stiripentol, ticlopidine, v muraf nib Carbamaz pine, fum e de cigarettes, ph nobarbital, ph nyto ne, primidone, rifampicine CYP2C8 Lop ramide, paclitaxel, pioglitazone, r paglinide Co-trimoxazole, d f rasirox, trim thoprime Rifampicine CYP2C9 Ac nocoumarol, c l coxib, co-trimoxazole, diclof nac, fluvastatine, glibenclamide, gliclazide, glim piride, glipizide, gliquidone, ibuprof ne, irb sartan, losartan, naprox ne, phenprocoumone, ph nyto ne, piroxicam, sulfam thoxazol, toras mide, warfarine Amiodarone, co-trimoxazole, fluconazole, fluox tine, fluvastatine, fluvoxamine, miconazole, sulfam thoxazole, voriconazole, zafirlukast Apr pitant.

2 Carbamaz pine, ph nobarbital, ph nyto ne, fosapr pitant, primidone, rifampicine, ritonavir CYP2C19 Citalopram, clopidogrel, diaz pam, escitalopram, som prazole, lansoprazole, moclob mide, om prazole, Cim tidine, som prazole, fluconazole, fluox tine, fluvoxamine, isoniazide, lansoprazole, moclob mide, Rifampicine pantoprazole, ph nobarbital, ph nyto ne, proguanil, rab prazole, stiripentol modafinil, om prazole, stiripentol, ticlopidine, topiramate, voriconazole CYP2D6 Amitriptyline, aripiprazole, atomox tine, carv dilol, clomipramine, cod ine, dapox tine, darif nacine, dextrom thorphane, dihydrocod ine, dulox tine, fl ca nide, halop ridol, imipramine, m toprolol, nortriptyline, parox tine, propaf none, propranolol, risp ridone, sertindole, tamoxif ne, timolol, tolt rodine, tramadol, venlafaxine Abirat rone, amiodarone, bupropione, c l coxib, chlorph namine, cim tidine, cinacalcet, citalopram, dapox tine, diphenhydramine, dulox tine, escitalopram, fluox tine, fluvoxamine, halop ridol, m thadone, mirab gron, moclob mide, parox tine, propaf none, ritonavir, sertraline, stiripentol, terbinafine, venlafaxine Rifampicine CYP3A4 Abirat rone, alfentanil, almotriptan, alprazolam, amiodarone, amlodipine, apixaban, apr pitant, aripiprazole, atazanavir, atorvastatine, axitinib, b tam thasone, boc pr vir, bosentan, brentuximab v dotine, bromocriptine, bud sonide, bupr norphine, cabazitaxel, carbamaz pine, chlorph namine, cicl sonide, ciclosporine, clarithromycine, colchicine, crizotinib, cyclophosphamide Amiodarone, apr pitant, atazanavir, boc pr vir, cim tidine, clarithromycine, crizotinib, darunavir, diltiazam, rythromycine, fluconazole, fluox tine, fluvoxamine, fosampr navir, fosapr pitant, imatinib, indinavir, itraconazole, k toconazole, lapatinib, linagliptine, lopinavir, pamplemousse/pom lo, pip raquine, posaconazole, ritonavir, saquinavir, stiripentol, t lapr vir, t lithromycine, tipranavir, v rapamil.

3 Voriconazole Bosentan, carbamaz pine, dapox tine, favirenz, millepertuis, modafinil, n virapine, ph nobarbital, ph nyto ne, primidone, rifabutine, rifampicine, vand tanib, vemuraf nib , dapox tine, darif nacine, darunavir, dasatinib, dexam thasone, dihydroergotamine, diltiazem, disopyramide, doc taxel, domp ridone, don p zil, dutast ride, l triptan, pl r none, ergotamine, erlotinib, rythromycine, estrog nes, estroprogestatifs, thinylestradiol, f lodipine, fentanyl, f sot rodine, fluticasone, fosampr navir, fosapr pitant, galantamine, g fitinib, halop ridol, hydrocortisone, imatinib, indinavir, irinot can, itraconazole, lapatinib, lop ramide, lopinavir, maraviroc, m thadone, m thylprednisolone, midazolam, nif dipine, nilotinib, nisoldipine, nitrendipine, oxybutynine, pazopanib, pimozide, pip raquine, prednisone, prednisolone, progestatifs, qu tiapine, rifabutine, rilpivirine, ritonavir, salm t rol, saquinavir, sertindole, sild nafil, simvastatine, sirolimus, solif nacine, soraf nib, sunitinib, tacrolimus, tadalafil, tamoxif ne, t lapr vir, temsirolimus, tipranavir, trazodone, triamcinolone, triazolam, ulipristal, vand tanib, vard nafil, v muraf nib, v rapamil, vinblastine, vincristine, vind sine, vinorelbine, zolpidem, zopiclone Tableau Ic.

4 Liste alphab tique des substrats , inhibiteurs et inducteurs des isoenzymes CYP Les substrats , les inhibiteurs et les inducteurs avec lesquels on s'attend des interactions cliniques particuli rement importantes sont indiqu s en caract res gras. Pour plus d'informations, voir Substrat de Inhibiteur de Inducteur de abirat rone 3A4 2D6 ac nocoumarol 2C9 alfentanil 3A4 almotriptan 3A4 alprazolam 3A4 amiodarone 3A4 2C9 2D6 3A4 amitriptyline 2D6 amlodipine 3A4 apixaban 3A4 apr pitant 3A4 3A4 2C9 aripiprazole 2D6 3A4 atazanavir 3A4 3A4 atomox tine 2D6 atorvastatine 3A4 axitinib 3A4

5 B tam thasone 3A4 boc pr vir 3A4 3A4 bosentan 3A4 3A4 brentuximab v dotine 3A4 bromocriptine 3A4 bud sonide 3A4 bupr norfine 3A4 bupropione 2D6 cabazitaxel 3A4 caf ine 1A2 1A2 carbamaz pine 3A4 1A2 2C9 3A4 carv dilol 2D6 c l coxib 2C9 2D6 chlorph namine 3A4 2D6 cicl sonide 3A4 Substrat de Inhibiteur de Inducteur de ciclosporine 3A4 cim tidine 1A2 2C19 2D6 3A4 cinacalcet 2D6 ciprofloxacine 1A2 citalopram 2C19 2D6 clarithromycine 3A4 3A4 clomipramine 2D6 clopidogrel 2C19 clozapine 1A2 cod ine 2D6 colchicine 3A4 co-trimoxazole 2C9 2C8 2C9 crizotinib 3A4 3A4 cyclophosphamide 3A4 dapox tine 2D6 3A4 2D6 3A4 darif nacine 2D6 3A4 darunavir

6 3A4 3A4 dasatinib 3A4 d f rasirox 2C8 dexam thasone 3A4 dextrom thorphane 2D6 diaz pam 2C19 diclof nac 2C9 diphenhydramine 2D6 dihydroergotamine 3A4 dihydrocod ine 2D6 diltiazem 3A4 3A4 disopyramide 3A4 doc taxel 3A4 domp ridone 3A4 Substrat de Inhibiteur de Inducteur de don p zil 3A4 dulox tine 1A2 2D6 2D6 dutast ride 3A4 favirenz 3A4 l triptan 3A4 pl r none 3A4 ergotamine 3A4 erlotinib 3A4 rythromycine 3A4 3A4 escitalopram 2C19 2D6 som prazole 2C19 2C19 estrog nes 3A4 1A2 estroprogestatifs 3A4 1A2 thinylestradiol 3A4 1A2 f lodipine 3A4 fentanyl 3A4 f sot rodine 3A4 fl ca nide 2D6

7 Fluconazole 2C9 2C19 3A4 fluox tine 2C9 2C19 2D6 3A4 fluticasone 3A4 fluvastatine 2C9 2C9 fluvoxamine 1A2 2C9 2C19 2D6 3A4 fosampr navir 3A4 3A4 fosapr pitant 3A4 3A4 2C9 fum e de cigarettes 1A2 galantamine 3A4 g fitinib 3A4 glibenclamide 2C9 gliclazide 2C9 Substrat de Inhibiteur de Inducteur de glim piride 2C9 glipizide 2C9 gliquidone 2C9 halop ridol 2D6 3A4 2D6 hydrocortisone 3A4 ibuprof ne 2C9 imatinib 3A4 3A4 imipramine 1A2 2D6 indinavir 3A4 3A4 irb sartan 2C9 irinot can 3A4 isoniazide 2C19 itraconazole 3A4 3A4 k toconazole 3A4 lansoprazole 2C19 2C19 lapatinib 3A4 3A4 linagliptine 3A4

8 Lop ramide 2C8 3A4 lopinavir 3A4 3A4 losartan 2C9 maraviroc 3A4 m latonine 1A2 m thadone 3A4 2D6 m thylprednisolone 3A4 m toprolol 2D6 miconazole 2C9 midazolam 3A4 millepertuis 3A4 mirabegron 2D6 moclob mide 2C19 2C19 2D6 Substrat de Inhibiteur de Inducteur de modafinil 2C19 3A4 naprox ne 2C9 n virapine 3A4 nif dipine 3A4 nilotinib 3A4 nisoldipine 3A4 nitrendipine 3A4 norfloxacine 1A2 nortriptyline 2D6 olanzapine 1A2 om prazole 2C19 2C19 oxybutynine 3A4 paclitaxel 2C8 pamplemousse 3A4 pantoprazole 2C19 parox tine 2D6 2D6 pazopanib

9 3A4 ph nobarbital 2C19 1A2 2C9 3A4 phenprocoumone 2C9 ph nyto ne 2C9 2C19 1A2 2C9 3A4 pimozide 3A4 pioglitazone 2C8 pirf nidone 1A2 pip raquine 3A4 3A4 piroxicam 2C9 pom lo 3A4 posaconazole 3A4 prednisone 3A4 prednisolone 3A4 primidone 1A2 2C9 3A4 Substrat de Inhibiteur de Inducteur de progestatifs 3A4 proguanil 2C19 propaf none 2D6 2D6 propranolol 2D6 qu tiapine 3A4 rab prazole