The Enzyme List Class 3 — Hydrolases

1 The Enzyme ListClass 3 HydrolasesNomenclature Committeeof theInternational Union of Biochemistry and Molecular Biology(NC-IUBMB)LATEX version prepared by Andrew McDonald,School of Biochemistry and Immunology, Trinity College Dublin, IrelandGenerated from the ExplorEnz database, March 2019 2019 IUBMBC ontentsEC Acting on ester bonds3EC Carboxylic-ester Hydrolases ..3EC Thioester Hydrolases .. 25EC Phosphoric-monoester Hydrolases .. 31EC Phosphoric-diester Hydrolases .. 54EC Triphosphoric-monoester Hydrolases .

2 63EC Sulfuric-ester Hydrolases .. 64EC Diphosphoric-monoester Hydrolases .. 68EC Phosphoric-triester Hydrolases .. 70EC Exodeoxyribonucleases producing 5 -phosphomonoesters .. 71EC Exodeoxyribonucleases producing 3 -phosphomonoesters .. 73EC Exoribonucleases producing 5 -phosphomonoesters .. 73EC Exoribonucleases producing 3 -phosphomonoesters .. 74EC Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5 -phosphomonoesters75EC Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3 -phosphomonoesters75EC Endodeoxyribonucleases producing 5 -phosphomonoesters.

3 75EC Endodeoxyribonucleases producing 3 -phosphomonoesters .. 78EC Site-specific endodeoxyribonucleases that are specific for altered bases .. 85EC Endoribonucleases producing 5 -phosphomonoesters .. 86EC Endoribonucleases producing 3 -phosphomonoesters .. 89EC Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5 -phosphomonoesters 90EC Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3 -phosphomonoesters 90EC Glycosylases91EC Glycosidases, enzymes that hydrolyseO-andS-glycosyl compounds.

4 91EC HydrolysingN-glycosyl compounds .. 138EC Acting on ether bonds145EC Thioether and trialkylsulfonium Hydrolases .. 145EC Ether Hydrolases .. 1461EC Acting on peptide bonds (peptidases)150EC Aminopeptidases .. 153EC Dipeptidases .. 159EC Dipeptidyl-peptidases and tripeptidyl-peptidases .. 162EC Peptidyl-dipeptidases .. 165EC Serine-type carboxypeptidases .. 166EC Metallocarboxypeptidases .. 167EC Cysteine-type carboxypeptidases .. 172EC Omega peptidases.

5 172EC Serine endopeptidases .. 176EC Cysteine endopeptidases .. 202EC Aspartic endopeptidases .. 218EC Metalloendopeptidases .. 228EC Threonine endopeptidases .. 248EC Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty) .. 248EC Acting on carbon-nitrogen bonds, other than peptide bonds251EC In linear amides .. 251EC In cyclic amides .. 279EC In linear amidines .. 283EC In cyclic amidines .. 288EC In nitriles .. 298EC In other compounds.

6 300EC Acting on acid anhydrides302EC In phosphorus-containing anhydrides .. 302EC In sulfonyl-containing anhydrides .. 315EC Acting on acid anhydrides to catalyse transmembrane movement of substances .. 316EC Acting on acid anhydrides to facilitate cellular and subcellular movement .. 320EC Acting on GTP to facilitate cellular and subcellular movement .. 322EC Acting on carbon-carbon bonds323EC In ketonic substances .. 323EC Acting on halide bonds328EC In carbon-halide compounds.

7 328EC Acting on phosphorus-nitrogen bonds331EC Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date) .. 331EC Acting on sulfur-nitrogen bonds332EC Acting on sulfur-nitrogen bonds (only sub-subclass identified to date) .. 332EC Acting on carbon-phosphorus bonds332EC Acting on carbon-phosphorus bonds (only sub-subclass identified to date) .. 332EC Acting on sulfur-sulfur bonds333EC Acting on sulfur-sulfur bonds (only sub-subclass identified to date) .. 333EC Acting on carbon-sulfur bonds333EC Acting on carbon-sulfur bonds (only sub-subclass identified to date).

8 333 References336 Index5022EC Acting on ester bondsThis subclass contains the esterase enzymes . The esterases are subdivided into: carboxylic-ester Hydrolases (EC ), thioesterhydrolases (EC ), phosphoric-monoester Hydrolases , the phosphatases (EC ), phosphoric-diester Hydrolases (EC ),triphosphoric-monoester Hydrolases (EC ), sulfuric-ester Hydrolases , the sulfatases (EC ), diphosphoric monoesterases(EC ) and phosphoric-triester Hydrolases (EC ). The nucleases, previously included under EC , are now placedin a number of new sub-subclasses: the exonucleases (EC ) and the endonucleases (EC ).

9 P EC and a previous edition, site-specific endodeoxyribonucleases were set out individually in subclasses EC and EC (since deleted), with 113 separate entries. These are now included in three entries EC , EC and EC Acomplete listing of all of these enzymes has been produced by Roberts and is available at Carboxylic-ester hydrolasesEC name:carboxylesteraseReaction:a carboxylic ester + H2O = an alcohol + a carboxylateOther name(s):ali-esterase; B-esterase; monobutyrase; cocaine esterase; procaine esterase; methylbutyrase; vitaminA esterase; butyryl esterase; carboxyesterase; carboxylate esterase; carboxylic esterase; methylbu-tyrate esterase.

10 Triacetin esterase; carboxyl ester hydrolase; butyrate esterase; methylbutyrase; -carboxylesterase; propionyl esterase; nonspecific carboxylesterase; esterase D; esterase B; esteraseA; serine esterase; carboxylic acid esterase; cocaine esteraseSystematic name:carboxylic-ester hydrolaseComments:Wide specificity. The enzymes from microsomes also catalyse the reactions of EC (arylesterase), EC (lysophospholipase), EC (acetylesterase), EC (acylglyc-erol lipase), EC (acylcarnitine hydrolase), EC (palmitoyl-CoA hydrolase), EC (amidase) and EC (aryl-acylamidase).