Transcription of Topics 5
1 771.. Topics 5.. 10 60 L/min .. PEEP . High-flow nasal cannula, Oxygen therapy, PEEP, Humidified oxygen . 068-0004 4 16-5.. E-mail: . 772 Topics 5 3 6 2014. 1 .. 1 High flow nasal prong therapy 2 High flow nasal cannula oxygen therapy 3 High-flow warned and humidified nasal oxygen 4 High flow therapy 5 Humidified high flow nasal cannula 6 High flow oxygen therapy . 7 Nasal high-flow therapy QOL .. 1 Nasal High Flow Fisher & Paykel Healthcare, Inc.. 2 High Flow Therapy System Pacific-Medico, lnc.. 3 Vapotherm High Flow Therapy Vapotherm, lnc.. 4 High Flow Humidification System Aquinox Pharma- ceuticals, Inc.. 1 . 1 1 .. 98 100 . 2 . 4 60 2 .. JIS .. high- ow nasal cannula . high- ow nasal can- 40 100 . nula oxygen therapy QOL . 21 100 .. QOL .. 1 . 30 40 L/min .. 773. 2 Fisher & Paykel Healthcare .. 1 COPD 76 1 . 300 ml L/s 36 L/. 120 L/min 4 . min .. 60 L/min . 100 L/min 60 L/ . min .. 2 30 . L/min 1 .. 3 .. 6 L/min 5 6 L/min .. 30 . 40 L/min 2 10 L/min . 1 COPD 15 L/min . 36 L/min.
2 36 L/min . 12 L/min 1 18 L/min .. 40 L/min . 1 .. 2 . 60 L/min .. 774 Topics 5 3 6 2014. PEEP . 1 . 0 .. 2 30 40 . 50 L/min SD cmH2O . cmH2O cmH2O . 8 . 3 PEEP .. 21 100 . PEEP . 4 alveolar recruitment . Corley 9 20 .. cmH2O PaO2/. 1 FiO2 mmHg . pharyngeal dead space washout .. 50. 6 .. ml 5 .. PaO2 1 3 7 .. Dewan 7 COPD 10 .. 2 6 QOL quality of life .. 3 PEEP . 40 . 775. 2 . COPD COPD .. ARDS.. QOL .. 2 .. 10 20 . L/min .. COI con icts of interest .. 1 .. 2005; 15; 264-9. 2 .. 1 PaCO2 48 Torr 2005; 43: 502-7. 3 Chanques G, et al. Discomfort associated with un- 2 derhumidi ed high- ow oxygen therapy in critical- 3 ly ill patients. Intensive Care Med 2009; 35: 996- II 1003. NPPV TPPV 4 L Her E, et al. Physiologic effects of noninvasive ventilation during acute lung injury. Am J Respir 10 L/min Crit Care Med 2005; 172: 1112-8. 5 . 2004; 13; 512-5. 6 Dysart K, et al. Research in high flow therapy: 776 Topics 5 3 6 2014. mechanism of action. Respir Med 2009; 103: 1400-5. 9 Corley A, et al.
3 Oxygen delivery through high- ow 7 Dewan N, et al. E ect of low ow and high ow ox- nasal cannulae increase end-expiratory lung vol- ygen delivery on exercise tolerance and sensation ume and reduce respiratory rate in post-cardiac of dyspnea. Chest 1994; 105: 1061-5. surgical patients. J Anaesthesia 2011; 107: 998-1004. 8 Parke RL, et al. The e ects of ow on airway pres- 10 Hasani A, et al. Domiciliary humidi cation improves sure during nasal high- ow oxygen therapy. Respir lung mucociliary clearance in patients with bron- Care 2011; 56: 1151-5. chiectasis. Chron Respir Dis 2008; 5: 81. Abstract High-flow nasal cannula oxygen therapy Kenji Miyamoto Hokkaido Chuo Rosai Hospital High-flow nasal cannula HFNC has lately been receiving considerable attention as a new oxygen-supplying device. Although nasal oxygen is administered at flows ranging from 10-60 L/min, it is not uncomfortable when the oxygen is warmed to body temperature and saturated to full humidity. The oxygen from HFNC has several beneficial effects: 1.
4 Pharyngeal dead space washout, 2 reduction of nasopharyngeal resistance; 3 a positive expiratory pressure that increas- es as oxygen flow increases; 4 an alveolar recruitment that increases end-expiratory lung volume with reduced respira- tory rate; 5 mucociliary clearance improvement; and 6 better control of FiO2. However, definitive recommendations about HFNC oxygen therapy will await more clinical studies.
