WHO International Biological Reference Preparations

1 Held and Distributed by the WHO International Laboratories for Biological StandardsWHO International Biological Reference PreparationsPREPARATIONSTANDARDMATERIALH ELD AT CODE WHO/BSDOCUMENTBLOOD PRODUCTS AND RELATED SUBSTANCES: Blood Anti-A blood grouping minimum potency reagent, Lyophilized, A 1 in 8 dilution defines the recommended minimum potency specification for anti-A blood grouping IgM (murine)03 International Standard, 2005 blood grouping minimum potency reagent, Lyophilized, A 1 in 4 dilution defines the recommended minimum potency specification for anti-B blood grouping IgM (murine)03 International Standard, 2005 NIBSCAnti-c incomplete blood typing serum, Lyophilized, 64 IU/ampouleHuman International Standard, 1976 NIBSCAnti-D (anti-Rho) minimum potency reagent, complete, Lyophilized, A 1 in 3 dilution defines the recommended minimum potency specification for low protein anti-D blood reagents.

2 A 1 in 8 dilution defines the recommended minimum potency specification for high protein anti-D IgM (human)99 Rev. 11st International Standard, 2004 B virus e antigen (anti-HBe), Lyophilized, 120 IU/mLHuman plasma129095/12 International Standard, 2013 B virus core antibodies (anti-HBc), Lyophilized, 50 IU/vialHuman plasma95 International Standard, 2008 NIBSCAnti-HIV antibodies (HIV-1 subtypes A, B, C, CRF01,_AE, group O and HIV-2), Lyophilized, No unitage plasma02 International Reference Panel, 2006 cruzi I antibody (TcI), Lyophilized, 1 IU / mlHuman plasma09 International Standard, 2011 cruzi II antibody (TcII), Lyophilized, 1 IU / mlHuman plasma09 International Standard, 2011 Barr virus DNA, Lyophilized, 5,000,000 IU/mlB95-8 strain formulated in universal buffer09 International Standard, 2011 A virus RNA, Lyophilized, 54,000 IU/mLHuman plasma00 International Standard, 2013 B Surface Antigen, Lyophilized.

3 , 50 IU / mlOther substances12 International Standard, 2014 B virus e antigen (HBeAg), Lyophilized, 100 IU/mLHuman serum129097/12 International Standard, 2013 B virus DNA, Lyophilized, 850,000 IU/vial (~ log10 IU/ml)Human plasma10 International Standard, 2011 B virus DNA, Genotypes A, B, C, D, E, F, G, Lyophilized, No unitage assignedHuman plasma5086/08 International Reference Panel, 2009 B virus surface antigen, fifteen panel members representing genotypes A-F and H, Lyophilized, No unitage assignedHuman plasma6100/09 International Reference Panel, 2011 Hepatitis B virus surface antigen, subtype adw2, genotype A, Lyophilized, 33 plasma00 International Standard, 2003 NIBSCPage 1 of 2 This Catalogue is available at the following WHO Web site address: February 2015 PREPARATIONSTANDARDMATERIALHELD AT CODE WHO/BSDOCUMENTBLOOD PRODUCTS AND RELATED SUBSTANCES: Blood Hepatitis B virus surface antigen, subtype adw2, genotype A, Lyophilized, Dilutional panel (IU/vial: ; ; ; ).

4 Human plasma03 International Reference Panel, 2003 C Virus core antigen, Lyophilized., 3,200 IU / mlOther substancesPEI code 129096 International Standard, 2014 C virus RNA, Lyophilized, 260,000 IU/ml (~ log10 IU/ml).Human plasma06 International Standard, 2011 /10665/96341/1 /10665/96341/1 /10665/96341/1 /10665/96341/1 D virus RNA, Lyophilized, 575,000 IU/mLHuman plasma7657/12 International Standard, 2013 E virus RNA, Lyophilized, 250,000 IU/mlHuman plasma10/6329 International Standard, 2011 Circulating Recombinant Forms (CRFs) RNA, ten panel members consisting of CRFs and other variants, Lyophilized, No unitage assignedHuman plasma13 International Reference Panel, 2013 NIBSCHIV-1 p24 antigen, Lyophilized, 1,000 IU/ampoulePeptide in human serum90 International Reference Reagent, 1992 RNA, Lyophilized, 185,000 IU/ml ( log10 IU/ml)HIV-1 genotype B isolate diluted in human plasma10 International Standard, 2011 RNA subtype Reference panel (A, B, C, D, AE, F, G, AG-GH, groups N and O)

5 , Lyophilized, No unitage assignedHuman plasmaCandidate HIV-1 NAT International Reference Panel, 2012 NIBSCHIV-2 RNA, Lyophilized, 1000 IU/vialHuman plasma08 International Standard, 2009 cytomegalovirus DNA, Lyophilized, 5,000,000 strain09 International Standard, 2010 B19 DNA, Lyophilized, 1,410,000 IU/mLParvovirus B19 positive donation diluted in plasma12 International Standard, 2013 B19 DNA, Genotypes 1,2,3a, negative control, Liquid frozen, No unitage assignedHuman plasma09 International Reference Panel, 2009 falciparum DNA, Lyophilized, 500,000,000 blood04 International Standard, 2006 , RBC4, RBC5, RBC12 blood group genotyping alleles, Lyophilized, No unitage assignedGenomic DNA10/232, 10/234, 10/236, 10 Reference Panel, 2011 /10665/137478/1 /10665/137478/1 /10665/137478/1 /10665/137478/1 gondii NAT assay, Lyophilized.

6 , 1,000,000 IU / mlOther substances10 International Standard, 2014 NIBSCPage 2 of 2 This Catalogue is available at the following WHO Web site address: February 2015