Transcription of 長年の謎「WPW症候群（ケント束）の起源」に解答？
1 What's New in Electrocardiology by JSE 2011. 4. 26 WPW Editorial Board Editorial Board 4 123 2 2 1 Notch Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. Rentschler S, et al. J Clin Invest.
2 2011;121:525-33. 2 AV canal Tbx2 Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. Aanhaanen WT, et al. J Clin Invest. 2011;121:534-44. WPW 1930 80 Page 1 of 2 WPW 2011/04/26 AV node 1 1 tubular heart atrioventricular AV canal AV canal AV node 2 1 AV canal 1 AV EMT annulus fibrosus AV node 1
3 1 123 2006-2011 Nikkei Business Publications, Inc. All Rights Reserved. Page 2 of 2 WPW 2011/04/26 's New in Electrocardiology by JSE 2011. 4. 26 WPW 123 AV node 2 AV node 3 1 2 3 EMT Tbx5 Gata4 Tbx2 EMT Tbx2 2 Page 1 of 2 WPW 2011/04/26 1 Notch 2 Tbx2 AV canal EMT annulus fibrosus Notch Tbx2 Notch Tbx2 WPW 2
4 Tbx2 Tbx2 AV canal AV canal Tbx3 Tbx2 Tbx3 1 Notch I WPW Q1 Q2 Q3 Q4 123 2006-2011 Nikkei Business Publications, Inc.
5 All Rights Reserved. Page 2 of 2 WPW 2011/04/26 's New in Electrocardiology by JSE 2011. 4. 26 WPW 123 epithelial-mesenchymal transition EMT EMT EMT EMT 3 1 2 3 EMT 3 EMT Page 1 of 3 WPW 2011/04/26 on/off on/off Tbx T-box 200
6 17 Tbx1 DiGeorge Tbx5 Holt-Oram Notch Notch Notch Notch Notch Notch1 4 Notch Delta DLL1 3 4 Jagged Jagged1 2 Notch Notch Notch Notch C Notch Intracellular Domain NICD NICD 4 NICD 3 Page 2 of 3 WPW 2011/04/26 Notch 1 EMT Notch Notch E off on 4 Notch 123 2006-2011 Nikkei Business Publications, Inc.
7 All Rights Reserved. Page 3 of 3 WPW 2011/04/26
