ESBL、メタロ-β-ラクタマーゼ、AmpC型 -ラクタマーゼ過剰 …
250 56 10 2010 . Q esbl . - - AmpC - . Double Disc Synergy Test . . . . A . . . . . 2. . 1 3 . extended - spectrum beta-lactamase esbl met- 1 . allo beta-lactamase MBL AmpC beta-lactamase - esbl . AmpC - - - . - . P. aeruginosa . Acinetobacter baumannii . . 3. . . esbl MBL AmpC MRSA. . esbl MBL AmpC VRE . . . 1. . . esbl MBL AmpC - . . . . . 18 . 251. . . esbl esbl ChromID esbl . CTX CPDX esbl . . 1. . esbl . CLSI Clinical and Laboratory Standards Institute . . CLSI esbl 2 . 2. . 3 . 4 . esbl . E. coli K. MIC . pneumoniae K. oxytoca P. mirabilis 4 . Salmonella Shigella Citrobacter koseri . esbl . . CLSI 2010 document M100 -S20 . CLSI esbl . 4, 6, 7 . CTX . 94% MIC 8 g/ml 1 g/ml IPM MEPM. 5 . 4 g/ml 1 g/ml . esbl . CAZ CTX . esbl . MicroScan SIEMENS BD . esbl E-test esbl . . esbl . DDST Double Disc Synergy Test . . DDST esbl . AmpC - . . MIC AmpC Ser- ratia marcescens Enterobacter cloacae Citrobacter DDST esbl 1 freundii . 8, 9 . AMPC/CVA . CAZ CTX . 1. . 79 . 5 9 . 97% 94 100% CLSI DDST.
Extended-spectrum beta-lactamase（ESBL）、met-allo beta-lactamase（MBL）、AmpC beta-lactamase （AmpC）は、いずれもβ-ラクタム系薬を加水分解 する酵素（β-ラクタマーゼ）のひとつであり、日常検 査で高頻度に検出される腸内細菌やP. aeruginosa、
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