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Human T cell development - Abcam

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TCR rearrangementTCR ,- rearrangementPro Tcell(DN1)CD10-/+CD7-/+CD135CD34CD10-/+C D7-/+CD135CD34T cell(DN2)CD7++CD5CD34TCR selectionMARROWTHYMUSBLOODMHC selectionApoptosisApoptosisCD7++CD1ACD34 T cell(DN3)CD8 -/+CD1ACD4T cell(ISP)CD8 -/+CD1ACD28CD71CD4Pre-TCRCD1AT cell(preDP) / T cellCD8 / TCR (V 24) / TCRCD4CD8 -/+ / TCRCD4-/+CD3CD3ID3highPLZFIL15IL7STATsBC L11BNOTCH1NOTCH, BCL11B, GATA3,TCF, SCF, IL7 (FLT3L)FOXP3RAG1,2NOTCHE2AHEBGATA3PTCRA (pT )TCF1LEFROR TGATA3TCF1ID3lowRUNX1HEBRAG1,2GATA3RUNX1 E2AHEBGATA3TH-POKMYBIFN , T-BET, STAT4, IL12, RUNX3IL4, GATA3, IL10, STAT6IL6, ROR T, IL23, IL1 , STAT3TGF , FOXP3STAT5IL15IL2IL7STAT5RUNX3Pre-TCR / TCRTCR rearrangementNKTcellCD8 -/+CD28CD4-/+CD3CD45ROCD45RACD56CD1D selection on DP thymocytesSLAM/SAP signalingMHC-II selected / TCRTregcellCD25CD4CD3CD31 / TCR / TCRTCcellCD8 CD3CD45RA- SelectionHigh MHC affinity+ SelectionIntermediate MHC affinity- SelectionNo MHC affinityCD1AMHC-IIMHC-I

Discover more at abcam.com/T-cells Produced in collaboration with Dr. Tom Taghon Human T cell development

  Development, Human, Cells, Human t cell development

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