Alkylation
Found 10 free book(s)Reactions of Amines
web.mnstate.eduAlkylation of 1º Alkyl Halides (Section 19-12, 19-21A) R Br RN H H N H R H X ammonium salt R 3a. Polyalkylation is routine. o With excess alkyl halide and base, keep on alkylating until it becomes the quaternary ammonium saltE (no surviving H’s on nitrogen, examples below) . Mechanism required for polylalkylations. The mechanism involves ...
Organometallic Chemistry - uni-regensburg.de
www-oc.chemie.uni-regensburg.de• Alkylation or hydroxyalkylation (i.e., reaction with RCHO) of enolates derived from conjugate addition of organocuprates affords vicinal dialkylated products. • However, the reaction is confined to highly reactive alkylating agents such as methyl, allyl, propargyl, benzyl, and α-halocarbonyl compounds or aldehydes.
Aldehydes can react with alcohols to form hemiacetals
www.chtf.stuba.skalkylation Meerwein's salt trimethyloxonium tetrafluoroborate oxonium ion alkylation •Formation of acetals and hemiacetals Hemiacetal formation is catalysed by acid or base, but acetal formation is possible only with an acid catalyst because an OH group must be made into a good leaving group. R R O ROH R R HO OR ROH R R RO OR catalysed by ...
Reactions of Benzene & Its Derivatives
colapret.cm.utexas.edu• Friedel-Crafts alkylation forms a new C-C bond between an aromatic ring and an alkyl group Cl AlCl3 + HCl Benzene 2-Chloropropane (Isopropyl chloride) Cumene (Isopropylbenzene) + The electrophilic partner is a carbocation; it will arrange to the most stable ion: allylic>3o>2o>1o.
Ketones and Aldehydes - Rutgers University
crab.rutgers.eduThe dithiane anion can react as a nucleophile with primary alkyl halides, and this alkylation generates a thioacetal. The hydrolysis of a thioacetal generates an aldehyde. Alternatively, the thioacetal can be further deprotonated and reacted with another (different) alkyl halide to generate a new thioacetal with two alkyl substituents.
Protecting Groups (PG) - ETH Z
ethz.chSide reaction: S‐alkylation, oxidation, lactonization Thioether PG O H N O S O O HF Cleavage O O H N OH S O R Homoserine lactone 12. Fmoc‐Strategy SPPS Fmoc: αNH Boc: Lysine, Tryptophan, Histidine
Fundamentals of Protein Chemistry - Duke GCB
genome.duke.eduCysteine Alkylation- prevents reoxidation to form disulfides. Alkylating Agents: Iodoacetamide, Vinylpyridine. Chemical Methods for Protein Characterization: Proteolysis. Chemical Methods: Acid Hydrolysis, various [H+], time, temp. Cyanogen Bromide cleavage, C-term to Methionine gives a homoserine lactone at Met.
Myers Stereoselective, Directed Aldol Reaction Chem 115
hwpi.harvard.edualkylation Open coordination site required for pericyclic aldol rxn RCHO Syn-Selective Aldol Reactions of Imide-Derived Boron (Z)-Enolates • Chiral controller group biases enolate !-faces such that one of the two diastereomeric (syn) transition states is greatly favored.
5.1 Petroleum Refining - US EPA
www3.epa.govPolymerization and alkylation processes are used to combine small petroleum molecules into larger ones. Isomerization and reforming processes are applied to rearrange the structure of petroleum molecules to produce higher-value molecules of a similar molecular size. 5.1.1.3 Treating Processes -
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