Biotransformation
Found 3 free book(s)Spiriva HandiHaler - Food and Drug Administration
www.accessdata.fda.govBiotransformation The extent of biotransformation appears to be small. This is evident from a urinary excretion of 74% of unchanged substance after an intravenous dose to young healthy volunteers. Tiotropium, an ester, is nonenzymatically cleaved to the alcohol N-methylscopine and dithienylglycolic acid,
DRUG NAME: Oxaliplatin - BC Cancer
www.bccancer.bc.caMetabolism rapid nonenzymatic biotransformation to reactive platinum complexes7 active metabolite(s) DACH platinum species 6 inactive metabolite(s) several conjugates, 6: including the 1,2-DACH-platinum dichloride (2%) associated with neurotoxicity: 3:
Biotransformation: Phase I and Phase II Metabolism
www.edukesh.com• Biotransformation: The goal of biotransformation is to convert lipophilic chemicals to more polar ones so that they can be eliminated more easily from the body. Most of the time this results in changes in the pharmacological activity of a drug. Although we ordinarily think of drug metabolism as a process that inactivates