Transcription of 規制基準委員会勉強会資料 110622 final - nihs.go.jp
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規制基準委員会勉強会資料 110622 final - nihs.go.jp
L . l . l ICH . l .. ( .. (ex vivo gene therapy). (in vivo gene therapy) 1) . ( ).. 2) . Viral vector Non-viral vector 3) .. Naked DNA ( plasmid ).. 120. 100. 80. 60. 40. 20. 0. 1989. 1994. 1998. 2004. 2008. 1990. 1991. 1992. 1993. 1995. 1996. 1999. 2000. 2001. 2002. 2003. 2005. 2006. 2009. 2010. 1997. 2007. Wiley J. Gene Medicine Gene Therapy Clinical Trials Worldwide . ( ) .. 30. 1084. 489. 100. 1703. Switzerland 50. UK 197. USA. 1084. Wiley J. Gene Medicine Gene Therapy Clinical Trials Worldwide . ( ) .. l ADA X-SCID . CGD Leber ALD . l . l . l . l ALS . l HIV B . l . l .. l .. 2% 1% 8%. 8%.. 8%. 65%.. 8%. Wiley ( ).. Others Unknown Lentivirus 4% 3%. 2% Bacteria HSV-1 1%. AAV. 3%. 5%. Adenovirus Poxvirus 24%.
†Ł^−Ł‰vz_„g˜0n’zO˛[Pl»vB–‹0nO‰ ‹ýT`T ÿINN) z.Ÿ^ ’i_Üu˙ Ł‰vzkµŒ” Advexin contusugene ladenovec Ad5-p53 0L0fi u3−¸StN ÿ|sVýÿ Cerepro sitimagene ceradenovec Ad5-HSV-TK ‘“‘’0°0Œ0“0ü0Þ u3−¸SÖ0−N 0Rÿk’]Þÿ 0‡0Ø0˘0‚0§0ó Beperminogene Perplasmid Plasmid …
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