Transcription of A Complete Solution for Method Linearity in HPLC and UHPLC
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A Complete Solution for Method Linearity in HPLC and UHPLC
A Complete Solution for Method Linearity in HPLC and UHPLCF rank Steiner, Fraser McLeod, Tobias Fehrenbach, and Andreas Brunner Dionex Corporation, Germering, GermanyNow sold under the Thermo Scientific brandIntroductIonValidation for Linearity requires the preparation and analysis of a set of several independently prepared solutions. As an example, according to ICH guidelines, HPLC Method Linearity is normally based on five concentration levels between 70% and 130% of the nominal concentration, each to be injected three times. The laboratory effort for this process can be substantial, especially if the Method is required to quantify several substances simultaneously. To save time, it is common to prepare only one stock Solution and subsequently dilute it to the different concentration levels.
Analyte Standard 1 Standard 2 Standard 3 Standard 4 Standard 5 Acesulfame K 7.390 9.730 9.930 11.450 13.650 Saccharin 2.695 3.480 3.890 4.305 5.085 ... is required by the operator is to name the peaks and enter their concentrations—a process that …
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