AASLDPRACTICEGUIDELINES Diagnosis and Management …

AASLD PRACTICE GUIDELINESD iagnosis and Management of autoimmune HepatitisMichael P. Manns,1 Albert J. Czaja,2 James D. Gorham,3 Edward L. Krawitt,4 Giorgina Mieli-Vergani,5 Diego Vergani,6and John M. Vierling7 This guideline has been approved by the AmericanAssociation for the Study of Liver Diseases (AASLD)and represents the position of the PreambleClinical practice guidelines are defined as systemati-cally developed statements to assist practitioner andpatient decisions about appropriate heath care for spe-cific clinical circumstances. 1 These guidelines onautoimmune hepatitis provide a data-supportedapproach to the Diagnosis and Management of this dis-ease. They are based on the following: (1) formalreview and analysis of the recently-published world lit-erature on the topic [Medline search]; (2) AmericanCollege of Physicians Manual for Assessing HealthPractices and Designing Practice Guidelines;2(3)guideline policies, including the AASLD Policy on theDevelopment and Use of Practice Guidelines and theAmerican Gastroenterological Association Policy State-ment on Guidelines;3and (4) the experience of theauthors in the specified recommendations, intended for use by physi-cians, suggest preferred approaches to the diagnostic,therapeutic and preventive aspects of care.

disease,8,9 asymptomatic patients must be followed life-long, preferably by an expert, to monitor for changes in disease activity. In children, the gamma glutamyl transferase level may be a better discriminator of biliary disease, Table 2. Codified Diagnostic Criteria of the International Autoimmune Hepatitis Group Features Definite Probable

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