Transcription of ACG Clinical Guideline: Diagnosis and Management of ...
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ACG Clinical Guideline: Diagnosis and Management of ...
Nature publishing group1 2015 by the American College of Gastroenterology The American Journal of GASTROENTEROLOGYPRACTICE guidelines Recent population studies suggest that gastroesophageal refl ux disease (GERD) is increasing in prevalence, both in the United States and worldwide ( 1,2 ). Th e Diagnosis of GERD is associated with a 10 15% risk of Barrett s esophagus (BE), a change of the normal squamous epithelium of the distal esophagus to a co-lumnar-lined intestinal metaplasia (IM). Risk factors associated with the development of BE include long-standing GERD, male gender, central obesity ( 3 ), and age over 50 years ( 4,5 ). Th e goal of a screening and surveillance program for BE is to identify in-dividuals at risk for progression to esophageal adenocarcinoma (EAC), a malignancy that has been increasing in incidence since the 1970s ( 6,7 ).
Shaheen et al. The American Journal of GASTROENTEROLOGY VOLUME XXX | XXX 2015 www.amjgastro.com 2 of evidence, we entered data from the papers of highest evidence into the GRADE program (accessible at www.gradepro.org ). For each recommendation, a GRADE table was …
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