Transcription of ACG Clinical Guideline: Genetic Testing and …
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ACG Clinical Guideline: Genetic Testing and …
Nature publishing group223 2015 by the American College of Gastroenterology The American Journal of GASTROENTEROLOGYPRACTICE guidelines Hereditary gastrointestinal (GI) cancer syndromes represent a phenotypically diverse group of disorders that exhibit distinct patterns of inheritance in an individual s progeny. Over the past few decades, the expansion of familial cancer registries and ad-vancement in genomics have led to the development of Clinical diagnostic criteria for specifi c hereditary syndromes as well as the discovery of multiple genes in which germline mutations predispose individuals to syndrome-associated neoplastic mani-festations.
Syngal et al. The American Journal of GASTROENTEROLOGY VOLUME 110 | FEBRUARY 2015 www.amjgastro.com 224 Table 1 . Summary statements Standard for minimal cancer family history assessment in gastrointestinal (GI) practice A family history of cancer and premalignant GI conditions that provides suffi cient information to …
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