Transcription of ASCO–CAP HER2 Test Guideline Recommendations
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ASCO–CAP HER2 Test Guideline Recommendations
ASCO CAP HER2 Test Guideline Recommendations Summary of Guideline 2007 and 2013 Recommendations Topic 2007 Recommendation 2013 Recommendation Specimens to All primary breast cancer specimens All newly diagnosed patients with breast cancer must have a be tested and metastases should have at least HER2 test performed. Patients who then develop metastatic one HER2 test performed disease must have a HER2 test performed in a metastatic site, if tissue sample is available. Optimal Positive for HER2 is either IHC HER2 3+ Must report HER2 test result as positive for HER2 if: a,b algorithm for (defined as uniform intense mem- HER2 testing brane staining of > 30% of invasive l IHC 3+ based on circumferential membrane staining that is tumor cells) or complete, intense c,d FISH amplified (ratio of HER2 to l ISH positive based on: CEP17 of > or average HER2 Single-probe average HER2 copy number ,e gene copy number > six signals/.)
ASCO–CAP HER2 Test Guideline Recommendations Summary of Guideline 2007 and 2013 Recommendations cap.org Topic 2007 Recommendation 2013 Recommendation
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