Transcription of CHAPTER 1 Identifying fetal abnormalities - Wiley-Blackwell
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CHAPTER 1 Identifying fetal abnormalities - Wiley-Blackwell
BLUK112-RubinOctober 9, 200710:34 CHAPTER 1 Identifying fetalabnormalitiesLena M. MacaraKey points Days 18 55 postconception is the time of maximal teratogenicpotential when most organs are differentiating Teratogenic effects of medications may affect both organ structureand organ function Detailed ultrasound assessment of the fetus by trained personnelshould detect most major structural abnormalities , but minorabnormalities are often undetected Patients at risk of neural tube defects (NTDs) should have 5 mg offolic acid daily for a minimum of 6 wk prior to conceptionIntroductionIt is estimated that 2 3% of all pregnancies in the United King-dom are affected by congenital abnormality. Almost half of theseabnormalities remain of uncertain aetiology, a further 25% maybe linked to a variety of genetic problems and only 2% are likelyto be associated with environmental factors that include this is a very small proportion of all birth defects, it is a crit-ical group, since the avoidance of some medications will preventthese abnormalities from o
BLUK112-Rubin October 9, 2007 10:34 CHAPTER 1 Identifying fetal abnormalities Lena M. Macara Key points Days 18–55 postconception is the time of maximal teratogenic
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