Transcription of Chapter 11
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Chapter 11
AbbreviationscAMP, cyclic adenosine monophosphateCNS, central nervous system5-CT, 5-carboxamidotryptamineDOB, 2,5-dimethyl-4-bromoamphetamineDOI, 2,5-dimethoxy-4-iodoamphetamineEMDT, 2-ethyl-5-methoxy-N,N-dimethyltryptamine GABA, g-aminobutyric acid5-HT, serotonin5-HTP, 5-hydroxytryptophanIBS, irritable bowel syndromeIBS-C, irritable bowel syndrome with constipationIBS-D, irritable bowel syndrome with diarrheaLCAP, long-chain arylpiperazineL-DOPA, L-dihydroxyphenylalanineLSD, lysergic acid diethylamideMAO, monomaine oxidaseMAOI, monoamine oxidase inhibitormCPBG, m-chlorophenylbiguanidemCPG, m-chlorophenylguanidinemCPP, m-chlorophenylpiperazinenM, nanomoles/LMT, melatoninMTR, melatonin receptorNET, norepinephrine reuptake transporter8-OH DPAT, 8-hydroxy-2-(di-n-propylamino)tetralinPM DT, 2-phenyl-5-methoxy-N,N-dimethyltryptamin eSAFIR, structure affinity relationshipSAR, structure activity relationshipSE
CHAPTER 11 / SEROTONIN RECEPTORS AND DRUGS AFFECTING SEROTONERGIC NEUROTRANSMISSION 367 and the then recently discovered hallucinogenic agent (+)-lysergic acid diethylamide (LSD) intrigued investi-gators. The observation led to speculation that 5-HT
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