Transcription of CHAPTER 3 Bias in randomized controlled trials
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CHAPTER 3 Bias in randomized controlled trials
CHAPTER 3 bias in randomized controlled trialsThe main appeal of the randomized controlled trial (RCT) in health care comes from its potential to reduce selection bias . Randomiza-tion, if done properly, can keep study groups as similar as possible at the outset, so that the investigators can isolate and quantify the effect of the interventions they are studying. No other study design gives us the power to balance unknown prognostic factors at base-line. Random allocation does not, however, protect RCTs against other types of existence of most biases related to RCTs is supported mainly by common sense. In recent years, however, important research efforts have used RCTs as the subject rather than the tool of research. These studies are usually designed to generate empirical evidence to improve the design, reporting, dissemination, and use of RCTs in health They have confirmed that RCTs are vulner-able to many types of bias throughout their entire life span.
CHAPTER 3 Bias in randomized controlled trials The main appeal of the randomized controlled trial (RCT) in health care comes from its potential to reduce selection bias.
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