Transcription of CITRIC ACID DETERMINATION
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CITRIC ACID DETERMINATION
CITRIC acid DETERMINATION BY AARON S. GOLDBERG AND ALICE R. BERNHEIM (From the Laboratory for the Study of Peripheral Vascular Diseases, Department of Surgery, the New York Hospital, and Cornell University Medical College, New York) (Received for publication, April 19, 1944) Three types of methods have been proposed for the DETERMINATION of CITRIC acid in urine. Salant and Wise (1) used the unspecific mercuric sulfate reagent of Deniges (2) in a study of the toxicity of citrates. Thun- berg (3) developed an enzymatic method employing a dehydrogenase said to be specific for citrate. The remaining methods depend on the so called pentabromoacetone method of Stahre (4), a qualitative test published in 1897 which Kunz (5), in 1914, used as the basis of the first quantitative pentabromoacetone method. It has been generally overlooked that in 1847 Cahours (6) prepared a bromination product from several citrates which he called bromoxaforme which according to his melting point and solubility data is without doubt identical with pentabromoacetone.
34 CITRIC ACID DETERMINATION the pentabromoacetone is isolated by ext.raction with petroleum ether. It is then treated with a sulfite solution, which we find destroys penta-
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