Transcription of Clean-in-place systems for industrial bioreactors: …
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Journal of industrial Microbiology, t3 (1994) 201-207. 9 1994 Society for industrial Microbiology 0169-4146/94/$ Published by The Macmillan Press Ltd Short Review Clean-in-place systems for industrial bioreactors: design, validation and operation Yusuf Chisti and Murray Moo-Young Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1. (Received 31 August 1993; accepted 31 March t994). Key words: Clean-in-place ; Automatic cleaning; Bioreactors SUMMARY. Guidelines for design, validationand operation of clean-in-placesystemsfor industrialfermentationplant are presented. Design of vessels, surface finishes, materials of construction, types and locations of valvesare some of the considerationsaddressed.
Journal of Industrial Microbiology, t3 (1994) 201-207 9 1994 Society for Industrial Microbiology 0169-4146/94/$09.00 Published by The Macmillan Press Ltd
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