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Coagulation

By 23 ACKNOWLEDGEMENTSWe gratefully acknowledge the support and funding provided by the Ontario Ministry of Healthand Long-Term thanks to the following people and organizations who provided their expertise inreviewing the content of this handbook: Gini Bourner (QMP-LS Hematology Committee) Dr. Jeannie Callum Dr. Allison Collins Dr. William Geerts Dr. Alejandro Lazo-Langner Dr. Ruth Padmore ( QMP-LS Hematology Committee) Anne Raby (QMP-LS Hematology Committee) Dr. Margaret Rand Dr. Alan TinmouthThanks also to: Dale Roddick, photographer, Sunnybrook Health Sciences Centre Reena Manohar, graphic artist, Sunnybrook Health Sciences Centre The ECAT FoundationCLOT-ED Images used or modified with permission from the ECAT Foundation, The Netherlands. March 2013 General Disclaimer:While the adv ice and information in this handbook are believed to be true and accurate at the time of publishing, neither the authors nor the publishers accept any legal responsibility or liability for any errors or omissions in the information provided, or for any of therecommendations made.

inhibitors of the extrinsic pathway factors (Factor VII) and common pathway factors (Factors X, V, II, Fibrinogen). International Normalized Ratio (INR) The International Normalized Ratio (INR) was developed to standardize the PT to allow for monitoring of oral vitamin K antagonist therapy (e.g. warfarin) across different labs.

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