Transcription of Coagulation in pregnancy - CSEN
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Coagulation in pregnancy - CSEN
7 Coagulation in pregnancyPatrick Thornton, BMSc, MBBCh, FCARCSI, Clinical Research Fellow,Joanne Douglas, MD, FRCPC, Clinical Professor*Department of Anesthesia, University of British Columbia, BC Women s Hospital, Vancouver, BC, CanadaKeywords:coagulationhaemostasisfib rinolysisplateletsthrombocytopaeniacoagu lation factorsfactor deficienciespregnancyheparinthrombophili aneuraxial anaesthesianeuraxial haematomaThe Coagulation system undergoes significant change duringpregnancy. The clinician caring for the parturient must understandthese changes, particularly when the parturient has a pre-existinghaematological condition. Because many haematological condi-tions are rare, there often is limited information to guide theobstetric and anaesthetic management of these parturients. 2009 Elsevier Ltd. All rights limit blood loss after trauma it is essential to seal bleeding vessels without affecting blood flowpermanently.
Other factors either remain at non-pregnant levels ordecrease during pregnancy. Factor XIII (FXIII), which is responsible for stabilising fibrin, increases in the first trimester but by term it is 50% of non-
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