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*Correspondence: Shah Riteshkumar R. Department of Pharmaceutics, Maliba Pharmacy College, Bardoli Mahuva Road, Dist- Surat -394 350 - State Guja-rat, India. E-mail: Journal of Pharmaceutical Sciencesvol. 47, n. 4, , 2011 Development and validation of dissolution method for carvedilol compression-coated tabletsRitesh Shah*, Sachin Patel, Hetal Patel, Sonia Pandey, Shailesh Shah, Dinesh ShahDepartment of Pharmaceutics, Maliba Pharmacy College, Bardoli, Surat, Gujarat, IndiaThe present study describes the Development and validation of a dissolution method for carvedilol compression-coated tablets. dissolution test was performed using a TDT-06T dissolution apparatus. Based on the physiological conditions of the body, hydrochloric acid was used as dissolution medium and release was monitored for 2 hours to verify the immediate release pattern of the drug in acidic pH, followed by pH in citric-phosphate buffer for 22 hours, to simulate a sustained release pattern in the intestine.
Development and validation of dissolution method for carvedilol compression-coated tablets 901 dissolution medium in a 25 ml volumetric flask and then
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