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Development of a new analytical method for …

*Correspondence: J. L. N. de Aguiar. Departamento de Qu mica, Instituto Nacional de Controle de Qualidade em Sa de, Funda o Oswaldo Cruz, Avenida Brasil, 4365 Manguinhos, 21045-900 - Rio de Janeiro RJ, Brasil. E-mail: Journal of Pharmaceutical Sciencesvol. 45, n. 4, , 2009 Development of a new analytical method for determination of acetylsalicylic and salicylic acids in tablets by reversed phase liquid chromatography Jos Luiz Neves de Aguiar*, Katia Christina Leandro, Shirley de Mello Pereira Abrantes, Andr Luis Mazzei AlbertDepartment of Chemistry, National Institute for Health Quality Control, Oswaldo Cruz FoundationAcetylsalicylic acid (AAS) is a drug utilized as analgesic, anti-inflammatory, and antipyretic medication, available worldwide and commonly used in Brazil. Salicylic acid (AS) is a precursor in AAS synthesis and is also produced during its degradation.

Development of a new analytical method for determination of acetylsalicylic and salicylic acids 725 following experimental outline: i) determination of the

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