Transcription of Development of mesalazine pellets coated with methacrylic ...
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Development of mesalazine pellets coated with methacrylic ...
*Correspondence: S. C. D o. Department of Pharmacy, Division of Health Sciences, Federal University of Paran . Av. Pref. Loth rio Meissner, 632 - Jardim Bot nico - 80210-170 Curitiba - PR, Brazil. E-mail: Journal of Pharmaceutical Sciencesvol. 47, n. 1, , 2011 Development of mesalazine pellets coated with methacrylic -derived polymerSimone Cristina D o1*, Itamar Francisco Andreazza1, Jo o Carlos Possamai21 Pharmacy Department, 2 Plant Science and Plant Health Department, Federal University of Paran mesalazine (5-ASA) is the standard drug for the treatment of inflammatory bowel disease (IBD) due to its local effect on intestinal and colonic mucosa. The effective and safe treatment of this disease requires more efficient delivery of the active substance to its site of action. The focus of this study was the use of multiparticulate systems, a modified release form in which the drug is divided into several functional subunits of release in the form of granules or pellets .
Development of mesalazine pellets coated with methacrylic-derived polymer 105 ples from the same batches was carried out by a black and white CCD video camera (Biocam-VI-6633-China) atta-
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