DRUG NAME: Pemetrexed

Pemetrexed drug NAME: Pemetrexed SYNONYM(S): COMMON TRADE NAME(S): ALIMTA CLASSIFICATION: Antifolate antimetabolite1,2 Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Like 5-fluorouracil and raltitrexed, Pemetrexed primarily inhibits thymidylate synthase (TS) resulting in decreased thymidine available for DNA Pemetrexed also inhibits dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT), which are key enzymes required for the de novo bio-synthesis of thymidine and purine Once Pemetrexed gains entry to the cell, through the reduced folate carrier, it is polyglutamated. Glutamation increases cellular retention and the intracellular half-life of Pemetrexed , as well as making the polyglutamated metabolites greater than 60-fold more potent in their inhibition of ,3 Pemetrexed is a radiation-sensitizing Pemetrexed induces cell cycle arrest in the G1/S PHARMACOKINETICS: Interpatient variability 19% for clearance plasma and interstitial compartments cross blood brain barrier?

The table includes adverse events that presented during drug treatment but may not necessarily have a causal relationship with the drug. Because clinical trials are conducted under very specific conditions, the adverse event rates observed may not reflect the rates observed in clinical practice. Adverse events are generally included if they

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